Objective: This study aimed to compare the Society of Fetal Urology (SFU) guidelines, the anteroposterior pelvic diameter (APD), and the urinary tract dilation (UTD) classification criteria for predicting the prognosis of antenatal hydronephrosis (AH). Materials and Methods: This was a retrospective analysis of the relationship among the three classification criteria and their contribution to the diagnosis and prognosis of possible AH in a cohort of neonates. Results: This study was a retrospective review of 290 neonates. The mean age was 16.4 ± 9.0 days, and 33% of the study population comprised female babies. An image review demonstrated that 35% of the patients had severe vesicoureteral reflux (VUR), 22% exhibited severe obstruction, 40% had transient hydronephrosis, and 9% required surgery. The antenatal SFU grading criteria demonstrated a significant relationship with severe obstruction, and the postnatal SFU grading was related to the severity of VUR. The highest sensitivity for the presence of VUR for surgical intervention was obtained for prenatal SFU-1 (100%). The highest specificity was for prenatal SFU-4 (96%) for the presence of VUR, prenatal SFU-4 (99%), and postnatal SFU-4 (94%) for surgical intervention. Conclusion: No reliable sonographic findings were found to predict VUR or severe ureteropelvic junction obstruction. The SFU grading during the postnatal period may predict VUR with low sensitivity and specificity. However, all three classification criteria contributed to the evaluation of the need for treatment in this cohort.