2024
DOI: 10.3389/fdsfr.2024.1380568
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Application of the target trial emulation framework to external comparator studies

Kellyn Arnold,
Luis Antunes,
Briana Coles
et al.

Abstract: External comparator (EC) studies are increasingly being used to generate evidence that supports the evaluation of emerging pharmacological treatments for regulatory and health technology assessment (HTA) purposes. However, the reliability of evidence generated from EC studies can vary. In this paper, we outline how an existing framework for causal inference, the target trial emulation (TTE) framework, can be appropriately applied to improve the design and analysis of EC studies. Applying the TTE framework invo… Show more

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