Large total electron content (TEC) variations along the line from Mars to Earth have been demonstrated by analyzing the ground received Tianwen‐1 differential one‐way range (DOR) signals when corona mass ejections (CMEs) and co‐rotating interaction regions (CIRs) pass through the signal path. Here, the TEC variations along the line from Mars to Earth are calculated from the Wang‐Sheeley‐Arge (WSA)‐Enlil space weather forecast model. The results are compared with the Tianwen‐1 line of sight (LOS) observations as well as the STEREO‐A in situ solar wind density measurements. It is found that the TEC variations calculated from the WSA‐Enlil model are usually much smaller in amplitude, especially in the cases of CIRs passing through the signal path. In addition, the timings of CMEs and CIRs passing through the DOR signal path in the WSA‐Enlil model can be half a day earlier or later than the observed ones. In comparison with in situ solar wind measurements, the ground received Tianwen‐1 DOR signals carry solar wind density information over a large spatial region along the signal path. Such remote sensing measurement can be valuable for constraining and improving global solar wind forecast models.