Application of the Tumor Site Recognizable and Dual-Responsive Nanoparticles for Combinational Treatment of the Drug-Resistant Colorectal Cancer

Shi, Ying; Shan, Shufang; Li, Chenghui; Song, Xian‐Rong; Zhang, Chaoxiong; Chen, Jiayi; You, Jia; Xiong, Jingyuan

doi:10.1007/s11095-020-02791-2

Cited by 14 publications

(5 citation statements)

References 36 publications

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“…Introducing impurities (dopants) into the nanoparticle's structure can alter its electronic or optical properties (Gunawan et al, 2015). This is widely used in semiconductor nanoparticles (quantum dots) to tune their emission wavelength or enhance their electrical conductivity (Shi et al, 2020).…”

Section: Dopingmentioning

confidence: 99%

Therapeutics Potential of Polysaccharide Based Nanocarriers: A Review

Dhingra,

Chauhan,

Chandra

et al. 2023

PLANT ARCHIVES

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Polysaccharide-based nanoparticles have garnered significant attention in recent years due to their unique properties and diverse applications in the biomedical field. These nanoparticles are fabricated from natural polysaccharides, such as chitosan, alginate, cellulose, starch, and hyaluronic acid, which offer inherent biocompatibility, biodegradability, and low toxicity, making them attractive candidates for drug delivery, imaging, and tissue engineering. This abstract provides a comprehensive overview of the synthesis, properties, and biomedical applications of polysaccharide-based nanoparticles. The synthesis methods encompass both chemical and physical approaches, including emulsification, nanoprecipitation, ionic gelation, and self-assembly techniques. These methods allow for precise control over nanoparticle size, shape, and surface characteristics, which directly impact their functionality and performance in various applications. Furthermore, polysaccharide-based nanoparticles find utility in medical imaging, providing contrast agents for enhanced diagnostic accuracy and disease monitoring. Additionally, they hold immense potential in tissue engineering, facilitating scaffold fabrication and promoting tissue regeneration through controlled release of growth factors and bioactive molecules.

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Section: Dopingmentioning

confidence: 99%

Therapeutics Potential of Polysaccharide Based Nanocarriers: A Review

Dhingra,

Chauhan,

Chandra

et al. 2023

PLANT ARCHIVES

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“…The photosensitizer Ce6 was covalently linked through the reduction-sensitive bond maleimide thioether to address the problem of drug leakage during application. Surface modification of the tumor homing peptide tLyp results in more precise targeting to tumor tissue [ 176 ].…”

Section: Targeted Nps In Crc Researchmentioning

confidence: 99%

Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer

et al. 2022

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Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and some patients are advanced at the time of diagnosis and have no chance for complete surgical resection. These factors make chemotherapy an indispensable and important tool in treating CRC. However, the complex composition of the tumor microenvironment and the interaction of cellular and interstitial components constitute a tumor tissue with high cell density, dense extracellular matrix, and high osmotic pressure, inevitably preventing chemotherapeutic drugs from entering and acting on tumor cells. As a result, a novel drug carrier system with targeted nanoparticles has been applied to tumor therapy. It can change the physicochemical properties of drugs, facilitate the crossing of drug molecules through physiological and pathological tissue barriers, and increase the local concentration of nanomedicines at lesion sites. In addition to improving drug efficacy, targeted nanoparticles also reduce side effects, enabling safer and more effective disease diagnosis and treatment and improving bioavailability. In this review, we discuss the mechanisms by which infiltrating cells and other stromal components of the tumor microenvironment comprise barriers to chemotherapy in colorectal cancer. The research and application of targeted nanoparticles in CRC treatment are also classified.

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“…As the expectation is to "take out two targets with one shot", researchers have just depicted the arising idea to engineer "intelligent" nanosystems for simultaneously realizing diagnosis and therapy. These nanosystems used in fighting against cancer are based on nanoplatforms which could efficiently co-entrap photosensitizers and chemotherapy, dendrimers, functional nanocarriers, drug-loaded nan-aggregates, liposomes, hybrid nanoparticles, and nanogels for "on-demand" anticancer drug delivery [137][138][139][140][141][142][143][144][145][146][147][148][149]. All of these systems are composed of multi-stimuli-responsive versatile materials, which enable them to ensure the expected requirements.…”

Section: Dual and Multi-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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Application of the Tumor Site Recognizable and Dual-Responsive Nanoparticles for Combinational Treatment of the Drug-Resistant Colorectal Cancer

Cited by 14 publications

References 36 publications

Therapeutics Potential of Polysaccharide Based Nanocarriers: A Review

Therapeutics Potential of Polysaccharide Based Nanocarriers: A Review

Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer

Smart Nanomaterials for Biomedical Applications—A Review

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