Application of tris(trimethylsilyl) phosphite as convenient phosphorus nucleophile in the direct synthesis of tetrasubstituted α-aminophosphonic acids from ketimines

Sequential Deprotonation–Alkylation of Binaphthyloxy-Substituted Phosphonochalcogenoates: Chiral Tri- and Tetrasubstituted Carbon Centers Adjacent to a Phosphorus Atom

“…To construct rare examples of chiral tetrasubstituted carbon centers, in particular, with three carbon-containing substituents, adjacent to a phosphorus atom, we then attempted the lithiation of ester 6h (Table ). However, under a variety of reaction conditions employing other bases and increasing the reaction temperature, the lithiation was unsuccessful and 6h remained mostly intact.…”