In recent years, mine site closure and rehabilitation have emerged as significant global challenges. The escalating number of abandoned mines, exemplified by over 60,000 in Australia in 2017, underscores the urgency. Growing public concerns and governmental focus on environmental issues are now jeopardising sustainable mining practices. This paper assesses the role of unmanned aerial vehicles (UAVs) in mine closure, exploring sensor technology, artificial intelligence (AI), and mixed reality (MR) applications. Prior research validates UAV efficacy in mining, introducing various deployable sensors. Some studies delve into AI’s use for UAV data analysis, but a comprehensive review integrating AI algorithms with MR methods for mine rehabilitation is lacking. The paper discusses data acquisition methods, repeatability, and barriers toward fully autonomous monitoring systems for mine closure projects. While UAVs prove adaptable with various sensors, constraints such as battery life and payload capacity impact effectiveness. Although UAVs hold potential for AI testing in mine closure studies, these applications have been overlooked. AI algorithms are pivotal for creating autonomous systems, reducing operator intervention. Moreover, MR’s significance in mine closure is evident, emphasising its application in the mining industry. Ultimately, a hybrid UAV–AI–MR technology is not only viable but essential for achieving successful mine closure and sustainable mining practices in the future.