Application of Umbilical Cord Serum Eyedrops for Recurrent Corneal Erosions

Abstract

In the treatment of recurrent corneal erosions, umbilical cord serum eyedrops may be effective in reducing the number of recurrences.

Plasma derived from human umbilical cord blood: Potential cell‐additive or cell‐substitute therapeutic for neurodegenerative diseases

“…A recent study showed beneficial functional improvement in an Alzheimer's disease (AD) mouse model by injection of a specific fraction from cord blood serum compared to adult blood serum. Additionally, umbilical cord serum has being effectively employed for the treatment of corneal defects and neurotrophic keratitis in humans.…”

Blood-derived topical therapy for ocular surface diseases

“…Yoon and colleagues demonstrated that UCS eye drops were even more effective than ASE in terms of symptom and keratoepitheliopathy scores in a group of 92 eyes with severe DES at 1 and 2 months post-treatment initiation 19. Recurrent corneal erosions were also more effectively managed with UCS eye drops than with artificial tears alone in another study by Yoon and colleagues 35. A comparison study of UCS versus ASE and artificial tears in the treatment of ocular chemical burns found UCS-treated patients to require significantly less days to complete corneal epithelialisation than those treated with ASE or artificial tears 38.…”

“…UCS may serve as a viable alternative in patients who are not good candidates for ASE therapy, such as those with graft-versus-host disease (GVHD) or SS, where pro-inflammatory cytokines could be present in the serum 63. UCS has potential applications in the treatment of PEDs,33 GVHD-associated dry eye,18 SS-type DES,19 recurrent corneal erosions35 and chemical burns 37 38. Yoon and colleagues demonstrated that UCS eye drops were even more effective than ASE in terms of symptom and keratoepitheliopathy scores in a group of 92 eyes with severe DES at 1 and 2 months post-treatment initiation 19.…”

“…Indications for which blood-derived therapy has been studied include DES caused by various aetiologies,6 9–27 PEDs,7 14 20 28–34 recurrent erosion syndrome,35 36 chemical injury37 38 and superior limbic keratoconjunctivitis 39. ASE, allogeneic serum, umbilical cord serum (UCS) and platelet-rich plasma (PRP) have all been studied for use in ocular surface disease.…”

Evaluation of the Role of Umbilical Cord Serum and Autologous Serum Therapy in Reepithelialization After Keratoplasty: A Randomized Controlled Clinical Trial

“…17 Both AS and UCS contain growth factors such as epidermal growth factor, acidic and basic fibroblast growth factor, plateletsderived growth factors, hepatocyte growth factor, vitamin A, transforming growth factor, substance P, insulin-like growth factors-1, nerve growth factor, fibronectin, and serum antiproteases (a 2-macroglobulin). [10][11][12][13][14][18][19][20][21] The UCS contains a much higher concentration of epidermal growth factor, vitamin A, acidic and basic fibroblast growth factor, fibronectin, nerve growth factor, substance P, a 2-macroglobulin as compared with AS. 12,14 In this study, we tested whether the UCS and AS have any added advantage compared with artificial tears (AT) in healing of postkeratoplasty EDs.…”