Application of Umbilical Cord Serum Eyedrops for the Treatment of Dry Eye Syndrome

Yoon, Kyung-Chul; Im, Seong-Kyu; Park, Yeoung-Geol; Jung, Young-Do; Yang, Seong-Yeul; Choi, Jung Sik

doi:10.1097/01.ico.0000183484.85636.b6

Cited by 83 publications

(81 citation statements)

References 23 publications

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“…Especially, EGF and TGF-b concentrations in umbilical cord serum are three and two times higher than those in autologous serum, respectively. 10 Although vitamin A concentration in umbilical cord serum is lower than that in peripheral blood serum, it is much higher than in tears and is sufficient to prevent squamous metaplasia. 10,12 Recently, several studies have been reported on the beneficial effect of 20% umbilical cord serum eyedrops in the treatment of dry eye syndrome and persistent epithelial defect of the cornea.…”

Section: Discussionmentioning

confidence: 99%

“…10 Although vitamin A concentration in umbilical cord serum is lower than that in peripheral blood serum, it is much higher than in tears and is sufficient to prevent squamous metaplasia. 10,12 Recently, several studies have been reported on the beneficial effect of 20% umbilical cord serum eyedrops in the treatment of dry eye syndrome and persistent epithelial defect of the cornea. 10,11,19 Umbilical cord serum led to faster healing of persistent corneal epithelial defects refractory to medical treatment compared to autologous serum.…”

Section: Discussionmentioning

confidence: 99%

“…10,12 Recently, several studies have been reported on the beneficial effect of 20% umbilical cord serum eyedrops in the treatment of dry eye syndrome and persistent epithelial defect of the cornea. 10,11,19 Umbilical cord serum led to faster healing of persistent corneal epithelial defects refractory to medical treatment compared to autologous serum. 19 Compared with autologous serum, umbilical cord serum has several advantages to treat dry eye associated with GVHD.…”

Section: Discussionmentioning

confidence: 99%

“…19 Compared with autologous serum, umbilical cord serum has several advantages to treat dry eye associated with GVHD. 10 It is not necessary to collect blood in GVHD patients themselves with blood dyscrasia and poor general condition. In addition, because a large amount of serum can be obtained from the umbilical vein at any one time, many patients can benefit from this sampling without waiting for additional preparations.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] Recently, we found that umbilical cord serum also contains many growth factors and essential tear components, and umbilical cord serum eyedrops are safe and effective for treating dry eye syndrome and persistent epithelial defect. [10][11] In the present study, we prospectively investigated the therapeutic effect of umbilical cord serum eyedrops on severe dry eye associated with GVHD.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Therapeutic effect of umbilical cord serum eyedrops for the treatment of dry eye associated with graft-versus-host disease

Yoon

Jeong

et al. 2007

Bone Marrow Transplant

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This study was performed to investigate the therapeutic effect of umbilical cord serum eyedrops on dry eye associated with graft-versus-host disease (GVHD). Twenty-four eyes of 12 patients with severe dry eye syndrome associated with GVHD were treated with 20% umbilical cord serum eyedrops. Symptom scoring, corneal sensitivity test, tear film break up time (BUT), Schirmer test, tear clearance rate (TCR), and corneal fluorescein staining were performed before and 2 and 6 months after treatment. Six months after treatment, significant improvement was observed in symptom score (from 3.8370.38 to 0.8370.57, Po0.01), corneal sensitivity (from 52.0876.06 mm to 57.5073.00 mm, Po0.01), tear film BUT (from 2.5070.91 s to 5.7171.04 s, Po0.01), and keratoepitheliopathy score (from 7.4272.02 to 1.2970.46, Po0.01). There was no siginificant change in Schirmer test and TCR results. No significant complications associated with the use of the eyedrops were observed. Umbilical cord serum eyedrops are safe and may be an effective way to treat severe dry eye associated with GVHD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Therapeutic effect of umbilical cord serum eyedrops for the treatment of dry eye associated with graft-versus-host disease

Yoon

Jeong

et al. 2007

Bone Marrow Transplant

View full text Add to dashboard Cite

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The landscape of clinical trials in corneal regeneration: A systematic review of tissue engineering approaches in corneal disease

Boroumand,

Rahmani,

Sigaroodi

et al. 2024

J Biomed Mater Res

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The limited availability of a healthy donor cornea and the incidence of allograft failure led researchers to seek other corneal substitutes via tissue engineering. Exploring the trend of clinical trials of the cornea with the vision of tissue engineering provides an opportunity to reveal future potential corneal substitutes. The results of this clinical trial are beneficial for future study designs to overcome the limitations of current therapeutic approaches. In this study, registered clinical trials of bio‐based approaches were reviewed for corneal regeneration on March 22, 2024. Among the 3955 registered trials for the cornea, 392 trials were included in this study, which categorized in three main bio‐based scaffolds, stem cells, and bioactive macromolecules. In addition to the acellular cornea and human amniotic membrane, several bio‐based materials have been introduced as corneal substrates such as collagen, fibrin, and agarose. However, some synthetic materials have been introduced in recent studies to improve the desired properties of bio‐based scaffolds for corneal substitutes. Nevertheless, new insights into corneal regenerative medicine have recently emerged from cell sheets with autologous and allogeneic cell sources. In addition, the future perspective of corneal regeneration is described through a literature review of recent experimental models.

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Umbilical Cord and Its Blood: A Perspective on Its Current and Potential Use in Ophthalmology

Yoon

2010

Regenerative Medicine Using Pregnancy-Specific Biological Substances

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Application of Umbilical Cord Serum Eyedrops for the Treatment of Dry Eye Syndrome

Abstract: Umbilical cord serum contains essential tear components, and umbilical cord serum eyedrops are effective and safe for the treatment of severe dry eye syndrome.

Cited by 83 publications

References 23 publications

Therapeutic effect of umbilical cord serum eyedrops for the treatment of dry eye associated with graft-versus-host disease

Therapeutic effect of umbilical cord serum eyedrops for the treatment of dry eye associated with graft-versus-host disease

The landscape of clinical trials in corneal regeneration: A systematic review of tissue engineering approaches in corneal disease

Umbilical Cord and Its Blood: A Perspective on Its Current and Potential Use in Ophthalmology

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