Application of Uniform Design Genetic Algorithm in Separation Condition Optimization of 14 Drugs

Zhang, T.; Chen, X.G.

doi:10.2991/eame-15.2015.153

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…However, a disadvantage is data processing derived from UD, which is made by special computer software, and statistical knowledge is necessary due to the absence of preestablished mathematical models [9]. UD is commonly applied for solving industrial problems and widely used in different fields of engineering, including pharmaceutical, chemical, and biological processes [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Takahashi

Rocha

Núñez

2016

Process Biochemistry

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This work objective was to define a modeling approach based on genetic algorithm (GA) for optimizing parameters of an artificial neural network (ANN); the latter describes rabies virus production in BHK-21 cells based on empirical data derived from uniform designs (UDs) with different numbers of experimental runs. The parameters considered for viral infection were temperature (34 and 37 • C), multiplicity of infection (0.04, 0.07, and 0.1), infection, and harvest times (24, 48, and 72 h), with virus production as the monitored output variable. A multilevel factorial experimental design was performed and used to train, validate, and test the ANN. Its experimental fractions (18, 24, 30, 36, and 42 runs) defined by UDs were used to simulate the neural architectures. In GA, the neural computing parameters constituted the population individuals, and the steps involved were population creation, selection, and replacement by crossover and mutation. The ANN optimized by the combined algorithm showed a good calibration for all UDs under consideration, thus demonstrating to be suitable (R > 0.85) as a correlation method in UDs independent of the experimental runs developed. Therefore, this work could guide researchers in the efficient use of UDs in the simulation and optimization of virus production processes.

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Section: Introductionmentioning

confidence: 99%

Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Takahashi

Rocha

Núñez

2016

Process Biochemistry

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Application of Uniform Design Genetic Algorithm in Separation Condition Optimization of 14 Drugs

Abstract: Abstract--An optimization method based on uniform design in conjunction with genetic algorithm was developed and applied in the optimization of separation condition of 14 drugs in reversedphase ion pair chromatography and satisfactory optimal result was obtained.

Cited by 1 publication

References 7 publications

Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

Optimization of artificial neural network by genetic algorithm for describing viral production from uniform design data

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