Application of UV spectrophotometric method to study stress degradation behavior of cefprozil

Abstract

Background: Cefprozil is a bactericidal drug that is used in the treatment of susceptible infections including upper and lower respiratory tract infections and skin and soft tissue infections. Materials and Methods: The objective of this research work was to develop and validate new, simple ultraviolet (UV) spectrophotometric method of Cefprozil in bulk and pharmaceutical dosage form and its application to study its stress degradation behavior. Results: The absorbance maxima peak was found at 280 nm, and linearity was observed in the concentration range of 2-10 µg/ml. The method was validated and found to be precise. Accuracy (percent recovery) for Cefprozil was found to be 99.117±1.005. Conclusion: A new method for estimation of Cefprozil by UV spectrophometry was developed and validated and Cefprozil was found to undergo degradation in all stress conditions.