Application of UVC and UVC based advanced disinfection technologies for the inactivation of antibiotic resistance genes and elimination of horizontal gene transfer activities: Opportunities and challenges

Ghosh, Shayok; Chen, Yiwei; Hu, Jiangyong

doi:10.1016/j.cej.2022.138234

Cited by 24 publications

(3 citation statements)

References 115 publications

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“…With the addition of H 2 O 2 in UV, • OH is the dominant reactive oxygen species (ROS) formed. Due to its nonselective oxidation ability, • OH could be consumed by the cell membrane or cytoplasmic components before reacting with iARGs. , Hence, different effects of • OH on the degradation of iARGs and eARGs were observed, i.e., negligible effects on iARG degradation together with enhanced eARG degradation. ,,,, For instance, with 10 mg/L H 2 O 2 and up to 180 mJ/cm 2 of UV irradiation, the LRVs of intracellular amp R were quite similar in UV and UV/H 2 O 2 , while the LRVs of extracellular amp R in UV/H 2 O 2 were obviously higher than those in UV. The fluence-based degradation rate constants of intracellular amp R (851 bp amplicon) with UV and UV/H 2 O 2 were (7.2 ± 0.35) × 10 –2 and (7.3 ± 0.30) × 10 –2 cm 2 mJ –1 , respectively.…”

Section: Elimination Efficiencies Of Iargs and Eargsmentioning

confidence: 99%

Elimination and Redistribution of Intracellular and Extracellular Antibiotic Resistance Genes in Water and Wastewater Disinfection Processes: A Review

Liu

et al. 2022

ACS EST Water

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Antibiotic resistance genes (ARGs) have been identified as emerging contaminants in water and wastewater. Concerns have been raised of whether disinfection processes can effectively eliminate ARGs and thus mitigate their spread. Due to the different existing forms and dissemination pathways, intracellular ARGs (iARGs) and extracellular ARGs (eARGs) have different responses to disinfection processes. This review compares the elimination of iARGs and eARGs in representative disinfection processes applied at water and wastewater treatment plants, including treatment by chlorine, chloramine, chlorine dioxide, ozone, ultraviolet irradiation (UV), and combination of UV with chemicals. Meanwhile, the redistribution of ARGs upon disinfection processes is highlighted. Elimination efficiencies of ARGs generally follow the order: ozone > chlorine ≫ chlorine dioxide > chloramine. The elimination of naked eARGs could be up to 4-log higher than that of iARGs. Notably, these disinfectants and the resulting disinfection byproducts formed in disinfection process can select antibiotic resistant bacteria (ARB) and increase relative abundances of iARGs. Under practical disinfectant exposure, elevated abundances of eARGs may be observed. Low doses of chlorine and chloramine tend to enhance the transfer of ARGs from intracellular to extracellular forms. To selectively control ARGs and associated risks and meanwhile minimize the unintended consequences, the disinfection practice may warrant optimization.

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Section: Elimination Efficiencies Of Iargs and Eargsmentioning

confidence: 99%

Elimination and Redistribution of Intracellular and Extracellular Antibiotic Resistance Genes in Water and Wastewater Disinfection Processes: A Review

Liu

et al. 2022

ACS EST Water

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“…UV disinfection is regarded as one of the most promising methods for disinfection, as it does not produce genotoxic secondary substances in the air or on surfaces that are exposed to it [4,5,6]. The UVC light-emitting diode (UVC LED) has emerged as an innovative and reliable solution for microbial inactivation, attributed to benefits such as mercuryfree production, flexible wavelength, long lifespan, compact size, and energy efficiency [7]. It is important to note that UV (ultraviolet) represents an electromagnetic spectrum encompassing UV-C, while UVC LED is a specific technology emitting light within this subset of the UV-C spectrum [8,9].…”

Section: Introductionmentioning

confidence: 99%

Autonomous Mobile Platform With Uv Ray Disinfection System, a Modular and Affordable Solution for Virus Elimination

2024

IJOMAM

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In the post-COVID erа, there hаs been а growing emphasis on the significance of disinfecting objects individuals come into contаct with. Mobile disinfection robots hаve emerged аs а definitive solution to meet this demаnd. However, inherent issues in their current design mаy pose chаllenges leаding to: continuous virus contamination (there is a risk that mobile UV robots may fail to reach all areas or fully eliminate pathogens, which could allow viruses to survive and subsequently spread infections); increase in the number of disease cases (incomplete disinfection may lead to the persistence of viruses in the environment, thereby increasing the likelihood of disease transmission and the emergence of a greater number of infection cases); illness among medical staff (if the environment in which medical staff operate is not fully disinfected, they may be exposed to the risk of infection with various pathogens, jeopardizing their health and ability to provide adequate medical care); the loss of human lives (inefficiency in disinfection can contribute to the spread of infectious diseases, leading to a higher number of deaths among the population, underscoring the need to address and resolve these issues). This scientific endeаvor аims to outline the primаry chаllenges аssociаted with conventional mobile disinfection robots and introduce a solution through the implementation of аn Аutonomous Mobile Plаtform equipped with а UV Ray Disinfection System. A critical issue identified in conventional mobile disinfection robots pertаins to their inаbility to ensure mаximum efficiency in preventing the spreаd of viruses. This limitаtion is often linked to their stаtic structure аnd the incаpacity to efficiently cover the entire space. Furthermore, the risk of continuous аthe introduction of аn Аutonomous Mobile Plаtform integrated with а UV Rаy Disinfhumection System. This innovаtive аpproаch effectively addresses existing limitations in conventional robots. The autonomous mobile plаtform enаbles comprehensive spаtial coverage, eliminating the risk of blind spots and ensuring uniform disinfection. The UV Rаy Disinfection System аdds аn аdditional layer of efficacy by molecularly destroying viruses and bаcteriа, thereby reducing the risk of contаminаtion. In summаry, this reseаrch introduces а technologically advanced and innovative solution to the chаllenges encountered with conventionаl mobile disinfection robots. The integrаtion of аn Autonomous Mobile Platform with a UV Ray Disinfection System opens opportunities for more efficient аnd secure disinfection of spаces, contributing to the mitigаtion of the risk of virus spreаd in the post-COVID period.

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“…The bacterial defense mechanisms against reactive oxygen species (ROS)-induced cellular damage may play a decisive role in total and antibioticresistant bacteria species. The DNA damage resulting from UV-based disinfection processes, including UV/H2O2 and UV/chlorination, remains tolerable due to the substantial effect of O ̇H on DNA structure and depletion by intracellular components [20]. Disinfectants such as chlorine and hypochlorous acid have also been found to promote the conjugative transfer of ARGs.…”

Section: Introductionmentioning

confidence: 99%

UV-VIS kaynaklı CFT-GO tabanlı pilot ölçek fotokataliz prosesinin konjugatif gen transfer mekanizmasına etkisininin belirlenmesi

ÖZKAL

2023

NÖHÜ Müh. Bilim. Derg.

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Bu çalışma, antimikrobiyal direncin kontrolünde (AMR) sürdürülebilir yaklaşımlar arasında olan, atıksuyun etkin dezenfeksiyonu üzerine kurulmuştur. Fotokataliz prosesi, ölçeklenebilir, araştırma ve geliştirmeye açık bir ileri oksidasyon prosesidir. Deneysel çalışmalarda kullanılan grafen-oksit-Ti-CuFe2O4 nanokompozit fotokatalizörleri, yeşil bir yaklaşımla sentezlenmiştir. Parabolik kolektör destekli fotoreaktörde, sub-letal fotokatalitik oksidasyonun alıcı ve verici E. coli suşları arasındaki konjugatif gen transferi mekanizmasına etkileri deneysel olarak araştırılmıştır. Farklı fotokatalizörlerin bakteri inaktivasyon hızı üzerine etkisi yanında, alıcı suşlarda eşleşmiş çiftlerin oluşumu (transkonjugant) frekansını ve nihai miktarını azaltan bir etki gösterdiği ortaa konulmuştur. Alıcı ve verici suşların eşzamanlı olarak fotokatalitik oksidasyona maruz kalması, her iki suş için de yaklaşık ~3 LOG giderim sağlamış ve transkonjugan oluşumunu kontrol edebilecek koşular oluşturmuştur. Fotokatalizör yüzeyi, reaktif oksijen türleri ve bakteriyel hücrelerin etkileşimi, ARG transferinin kontrolünde belirleyici bir rol oynamıştır. Alıcı hücrelerin canlılığı üzerindeki fotokatalitik oksidasyon mekanizmalarının etkisi, konjugatif ARG transferinin azaltıldığı sürekli işletme sırasında açıkça görülmüş ve transkonjuganların sayısı 102 CFU mL-1'nin altına düşmüştür. Bu çalışma, PC'nin atıksu arıtımında etkili dezenfeksiyon ve AMR kontrolü için potansiyelini göstermektedir."

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Application of UVC and UVC based advanced disinfection technologies for the inactivation of antibiotic resistance genes and elimination of horizontal gene transfer activities: Opportunities and challenges

Cited by 24 publications

References 115 publications

Elimination and Redistribution of Intracellular and Extracellular Antibiotic Resistance Genes in Water and Wastewater Disinfection Processes: A Review

Elimination and Redistribution of Intracellular and Extracellular Antibiotic Resistance Genes in Water and Wastewater Disinfection Processes: A Review

Autonomous Mobile Platform With Uv Ray Disinfection System, a Modular and Affordable Solution for Virus Elimination

UV-VIS kaynaklı CFT-GO tabanlı pilot ölçek fotokataliz prosesinin konjugatif gen transfer mekanizmasına etkisininin belirlenmesi

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