Clinical decision support systems are computer systems that help decision-makers make effective and efficient decisions in the diagnosis and treatment of diseases, patient care, and health institution management. In this study, descriptive and bibliometric analyses were carried out of studies on clinical decision support systems conducted between 2016 and 2021 in journals included in the Web of Science database. In the first stage, the distribution of the articles was determined according to the publication year, country, institution, journal and citation numbers within the scope of descriptive analysis. In the second stage, within the scope of bibliometric analysis, co-author-institution, co-citation-author, cocitation-country and common keyword analysis of the articles were made. As a result of the research, 8052 articles on clinical decision support systems were reached. It was observed that the country with the most studies on this subject are the United States and the institution is Harvard University. It was seen that the journal with the highest number of articles was PLOS ONE. In addition, co-citations, institutional and country collaborations between authors are presented with visual maps. The purpose of this study is to present the studies on clinical decision support systems in a systematic framework and to provide a broad perspective to the researchers and field experts working on this subject.