Application of zirconium MOFs in drug delivery and biomedicine

Lázaro, Isabel Abánades; Forgan, Ross S.

doi:10.1016/j.ccr.2018.09.009

Cited by 553 publications

(203 citation statements)

References 144 publications

(178 reference statements)

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“…Previously, we and others have shown that UiO‐66 is biocompatible, while the cytotoxicity of DCA ‐loaded MOFs is dependent on surface chemistry, and incorporation of a second drug can dramatically enhance overall cytotoxicity . As well as DCA , we have chosen α‐cyano‐4‐hydroxycinnamic acid ( α‐CHC ), a molecule recently proposed as an anticancer agent, due to the relatively low p K a of its carboxylate unit (2.2), comparable with the one of DCA (1.4).…”

Section: Resultsmentioning

confidence: 99%

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

2020

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Metal–organic frameworks (MOFs) are emerging as leading candidates for nanoscale drug delivery, as a consequence of their high drug capacities, ease of functionality, and the ability to carefully engineer key physical properties. Despite many anticancer treatment regimens consisting of a cocktail of different drugs, examples of delivery of multiple drugs from one MOF are rare, potentially hampered by difficulties in postsynthetic loading of more than one cargo molecule. Herein, we report a new strategy, multivariate modulation, which allows incorporation of up to three drugs in the Zr MOF UiO‐66 by defect‐loading. The drugs are added to one‐pot solvothermal synthesis and are distributed throughout the MOF at defect sites by coordination to the metal clusters. This tight binding comes with retention of crystallinity and porosity, allowing a fourth drug to be postsynthetically loaded into the MOFs to yield nanoparticles loaded with cocktails of drugs that show enhancements in selective anticancer cytotoxicity against MCF‐7 breast cancer cells in vitro. We believe that multivariate modulation is a significant advance in the application of MOFs in biomedicine, and anticipate the protocol will also be adopted in other areas of MOF chemistry, to easily produce defective MOFs with arrays of highly functionalised pores for potential application in gas separations and catalysis.

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Section: Resultsmentioning

confidence: 99%

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

2020

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“…MOFs, as compared to traditional porous materials, possess predominance of large surface areas, tunable pore size and shape, adjustable composition, and functionalized pore surface, which confer to them unique advantages for promising applications in adsorption and the release of therapeutic agents [66,74]. In this sense, the use of zirconium-based MOFs for drug delivery and biomedicine applications has been recently reviewed due to the their optimal stability towards hydrolysis and post-synthetic modifications with low toxicity [75]. Photocatalytic applications of MOFs have also been widely analysed due to their semiconductor properties [78].…”

Section: Metal Organic Framework (Mofs)mentioning

confidence: 99%

A Review on the Synthesis and Characterization of Metal Organic Frameworks for Photocatalytic Water Purification

et al. 2019

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This review analyzes the preparation and characterization of metal organic frameworks (MOFs) and their application as photocatalysts for water purification. The study begins by highlighting the problem of water scarcity and the different solutions for purification, including photocatalysis with semiconductors, such as MOFs. It also describes the different methodologies that can be used for the synthesis of MOFs, paying attention to the purification and activation steps. The characterization of MOFs and the different approaches that can be followed to learn the photocatalytic processes are also detailed. Finally, the work reviews literature focused on the degradation of contaminants from water using MOF-based photocatalysts under light irradiation.

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“…Owing to their highly tunable surface areas and pore volumes, frameworks have been successfully implicated in an expanding number of applications including selective gas sorption, separations, sensing and drug delivery [25,26]. A recent trend that has emerged over the past decade is the incorporation of redox-active components into frameworks.…”

Section: (B) Towards Infinitely Tunable Open Framework Coordination Cmentioning

confidence: 99%

Prospects for electroactive and conducting framework materials

Murase

Ding

et al. 2019

Phil. Trans. R. Soc. A.

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Electroactive and conducting framework materials, encompassing coordination polymers and metal–organic frameworks, have captured the imagination of the scientific community owing to their highly designable nanoporous structures and their potential applications in electrochromic devices, electrocatalysts, porous conductors, batteries and solar energy harvesting systems, among many others. While they are now considered integral members of the broader field of inorganic materials, it is timely to reflect upon their strengths and challenges compared with ‘traditional’ solid-state materials such as minerals, pigments and zeolites. Indeed, the latter have been known since ancient times and have been prized for centuries in fields as diverse as art, archaeology and industrial catalysis. This opinion piece considers a brief historical perspective of traditional electroactive and conducting inorganic materials, with a view towards very recent experimental progress and new directions for future progress in the burgeoning area of coordination polymers and metal–organic frameworks. Overall, this article bears testament to the rich history of electroactive solids and looks at the challenges inspiring a new generation of scientists. This article is part of the theme issue ‘Mineralomimesis: natural and synthetic frameworks in science and technology’.

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Application of zirconium MOFs in drug delivery and biomedicine

Cited by 553 publications

References 144 publications

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

Multivariate Modulation of the Zr MOF UiO‐66 for Defect‐Controlled Combination Anticancer Drug Delivery

A Review on the Synthesis and Characterization of Metal Organic Frameworks for Photocatalytic Water Purification

Prospects for electroactive and conducting framework materials

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