Application of α-Aminoalkyl Radicals as Reaction Activators

Abstract

α-Aminoalkyl radicals are easily accessible through multiple pathways from various precursors. Apart from their utilization as N-containing building blocks, they have recently been used as halogen atom abstraction reagents or single-electron reductants to transform organic halides or sulfonium salts to their corresponding highly reactive radical species. Benefiting from the richness of various halides and the diverse reactivity of radical intermediates, new transformations of halides and sulfonium salts have been developed. This short review summarizes this emerging chemistry that uses α-amino radicals as the reaction activators.