Application Prospect and Preliminary Exploration of GelMA in Corneal Stroma Regeneration

Abstract

Corneal regeneration has become a prominent study area in recent decades. Because the corneal stroma contributes about 90% of the corneal thickness in the corneal structure, corneal stromal regeneration is critical for the treatment of cornea disease. Numerous materials, including deacetylated chitosan, hydrophilic gel, collagen, gelatin methacrylate (GelMA), serine protein, glycerol sebacate, and decellularized extracellular matrix, have been explored for keratocytes regeneration. GelMA is one of the most prominent materials, which is becoming more and more popular because of its outstanding three-dimensional scaffold structure, strong mechanics, good optical transmittance, and biocompatibility. This review discussed recent research on corneal stroma regeneration materials and related GelMA.

3D-Bioprinted Biomimetic Multilayer Implants Comprising Microfragmented Adipose Extracellular Matrix and Cells Improve Wound Healing in a Murine Model of Full-Thickness Skin Defects

“…Gelatin methacrylate (GelMA) is produced by modifying gelatin with methacrylate . Gelatin, a biodegradable polypeptide, is a hydrolytic product of collagen . In the whole tissue MT-stained section, strips or patches of homogeneous blue-dyed areas representing the implants were visible (Figure ).…”

“…57 Gelatin, a biodegradable polypeptide, is a hydrolytic product of collagen. 58 In the whole tissue MT-stained section, strips or patches of homogeneous blue-dyed areas representing the implants were visible (Figure 11). The other collagen source was native collagen in the wound.…”

Biomaterial in Microencapsulation: How Microencapsulation is Changing the Medicine World

“…Biocompatibility, biodegradability and low cost makes GelMA [143] useful in drug delivery [144], cell delivery [145], gene delivery [146], vaccine delivery [147], wound healing [148,149], and tissue regeneration [150]. Also, GelMA has broad applications in biomedical field such as corneal regeneration [151], bone repair [152,153], myocardial infarction [154,155], hemostasis control [156], and vascular regeneration [157,158].…”

A “T.E.S.T.” hydrogel bioadhesive assisted by corneal cross-linking for in situ sutureless corneal repair

“…The gelatin-based hydrogels with various cross-linking strategies have been developed for corneal repair [ 12 , 14 , 15 ]. Among them, gelatin methacryloyl (GelMA) is most widely used as a corneal substitute due to its controlled cross-linking under light irradiation, which is convenient for the preparation of in-situ curable hydrogels that can precisely fill the corneal damage with different shapes [ 16 ]. Of note, in-situ light-curable GelMA-based hydrogels are reported to show certain anchoring ability on corneal tissue [ 17 , 18 ].…”