2023
DOI: 10.1248/bpb.b23-00561
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Application Site of Transdermal Scopolamine Influences Efficacy and Drug Concentration in Salivary Glands in Rats

Natsuko Ishida,
Yoshitaka Oshima,
Ayano Katsura
et al.

Abstract: Transdermal scopolamine applied to the postauricular area is used to treat drooling. We investigated the duration of action of scopolamine ointment and the effect of the application site on drug efficacy and concentration in the salivary glands of rats. Scopolamine ointment was applied to the skin over the salivary glands (SSG) and back (SB). Saliva volume was measured after intraperitoneal administration of pilocarpine. Blood and salivary glands were collected after scopolamine ointment application, and scopo… Show more

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