Application, structure, salts and complexes of lidocaine: a review. Part VI. Thiocyanate complexes

Abstract

The review focuses on lidocaine (2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide), one of the most popular and widely used painkillers. This part of the review is an introduction to our results from studying the structure of two thiocyanate complexes of lidocaine. The properties of the thiocyanate group, the use of infrared spectroscopy to study the structure of lidocaine-containing compounds, and the infrared spectra of thiocyanates are considered. The work on studying the structure of thiocyanate and other lidocaine complexes, carried out in the 1990s by a group of researchers from the University of Mysore, Manasagangotri, India, is considered. It is shown that in all 15 structures studied, the protonation of the lidocaine molecule with the formation of the LidH+ cation, as well as subsequent formation of a charge transfer complex and a network of hydrogen bonds, were not taken into account.