The course of drug design is a new interdisciplinary subject developed from multiple disciplines, with the research methods of innovative new drugs as the main content. It covers a wide range of knowledge points. Taking teaching this course to the Pharmaceutical students in Chifeng University as an example, this paper makes a preliminary exploration from many aspects such as clarifying the teaching objectives, Selection of the teaching contents, having a good first class, diversified teaching design models, diversified assessment methods, making full use of network resources and moral education throughout the whole process, aiming to provide reference for the training of innovative Drug Development staff in the future.