Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

Zhang, Mei‐Jie; Park, Gajin; Zhou, Bingrong; Luo, Dan

doi:10.1111/jocd.12673

Cited by 64 publications

(54 citation statements)

References 33 publications

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“…Platelet‐based autologous therapies have created a new field in regenerative dermatology . There are many products to choose from, when using platelet‐based autologous therapies.…”

Section: Discussionmentioning

confidence: 99%

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

Kao¹

2019

International Wound Journal

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Treating chronic skin wounds in patients with diabetes, bed sores, or stasis dermatitis is typically a time-consuming and costly process, and the outcome is not always promising. Concentrated growth factor (CGF) obtained from the autologous venous blood of patients via fractional centrifugation is employed for producing a CGF gel or membrane that can be applied to expedite self-regeneration of skin wounds. In this case report, we presented the results from 18 patients with chronic skin wounds treated with a CGF gel or membrane produced from autologous venous blood. Noticeable granulation tissue and regenerated epidermal coverage were observed in 16 patients who received CGF treatment over various time courses, thereby demonstrating the significant therapeutic effects of CGF treatment in overall wound healing. The other two patients with stasis ulcers in their calves failed to respond to the treatment because of the comorbidity of iliac vein thrombosis. In addition, by culturing HaCaT keratinocytes using CGF membrane as the foundation, we observed that HaCaT cells attached to the CGF membrane migrated and proliferated to form an epithelium-like structure. Comprehensively, the clinical results infer that CGF gel can expedite the regeneration of the soft tissue at the wound, whereas CGF membrane may facilitate its marginal re-epithelialisation. The combination of the two can promote autologous regeneration of both deep and superficial wounds effectively and safely.

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“…Platelet‐based autologous therapies have created a new field in regenerative dermatology . There are many products to choose from, when using platelet‐based autologous therapies.…”

Section: Discussionmentioning

confidence: 99%

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

Kao¹

2019

International Wound Journal

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“…Os fatores de crescimento são liberados após a ativação endógena ou exógena das plaquetas e, em seguida, agem direta e indiretamente para regenerar o tecido (AUST et al, 2018;ZHANG et al, 2018). Algumas poucas plaquetas são ativadas por influências mecânicas durante a centrifugação.…”

Section: Envelhecimento Cutâneounclassified

“…Dependendo da metodologia aplicada, diferentes concentrações de plaquetas serão obtidas, o que pode influenciar na qualidade e eficácia do produto. Diversos protocolos têm sido propostos com diferentes variáveis dentro do processo, como o número de rodada de centrifugações, tempo e força centrífuga, volume de sangue, disso, como a contagem de plaquetas possui ampla variação de um indivíduo para o outro, pois volumes iguais de sangue total resultariam em concentrações finaisCHORAZEWSKA et al, 2017;ZHANG et al, 2018). Os fatores de crescimento possuem meia-vida curta (de minutos a horas), e se não forem utilizados imediatamente após a ativação, podem ser degradados antes que os receptores adicionais estejam disponíveis no tecido(CAVALLO et al, 2016).…”

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O uso do plasma rico em Plaquetas no Rejuvenescimento Facial: Uma Revisão Integrativa / Use of rich Plasma on platelets in Facial Rejuvenation: An Integrating Review

et al. 2019

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O plasma rico em plaquetas é um concentrado autólogo de plaquetas e fatores de crescimento. Tem sido utilizado há décadas em várias especialidades da área da saúde e, recentemente, evidências para aplicações na área estética vêm sendo desenvolvidas. Assim, o objetivo do estudo foi realizar uma revisão integrativa sobre o uso intradérmico do plasma rico em plaquetas para rejuvenescimento facial, baseado em evidências clínicas. Nove estudos foram incluídos na síntese interpretativa. Foram encontradas diferenças entre o método de obtenção do plasma, doses e o tamanho da amostra, que variou de 10 a 31 indivíduos, tornando os resultados com evidência pouco suficiente. Entretanto, a melhora na aparência da pele e das rugas foi estatisticamente significativa em todos os estudos, tanto após administrações únicas quanto após mais sessões de tratamento, o que demonstra a aplicação promissora do plasma rico em plaquetas, que pode ser integrado na prática estética para o rejuvenescimento facial.

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“…Platelets, owing to the high content of native growth factors, chemokines and cytokines in their α-granules, represent a cost-effective and possibly autologous reservoir of bioactive molecules, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β) or Regulated upon Activation, Normal T Cell Expressed and Secreted (RANTES) [ 11 , 12 , 13 ]. Platelet products have recently been used in various applications in dermatology, including face rejuvenation procedures [ 14 , 15 ], hair regrowth [ 16 ] or scar management [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment

et al. 2020

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Vitiligo is the most common depigmentation disorder of the skin. Currently, its therapy focuses on the halting of the immune response and stimulation of the regenerative processes, leading to the restoration of normal melanocyte function. Platelet-rich plasma (PRP) represents a safe and cheap regenerative therapy option, as it delivers a wide spectrum of native growth factors, cytokines and other bioactive molecules. The aim of this study was to develop a simple delivery system to prolong the effects of the bioactive molecules released from platelets. The surface of electrospun and centrifugally spun poly-ε-caprolactone (PCL) fibrous scaffolds was functionalized with various concentrations of platelets; the influence of the morphology of the scaffolds and the concentration of the released platelet-derived bioactive molecules on melanocytes, was then assessed. An almost two-fold increase in the amount of the released bioactive molecules was detected on the centrifugally spun vs. electrospun scaffolds, and a sustained 14-day release of the bioactive molecules was demonstrated. A strong concentration-dependent response of melanocyte to the bioactive molecules was observed; higher concentrations of bioactive molecules resulted in improved metabolic activity and proliferation of melanocytes. This simple system improves melanocyte viability, offers on-site preparation and is suitable for prolonged topical PRP administration.

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Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

Cited by 64 publications

References 33 publications

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

O uso do plasma rico em Plaquetas no Rejuvenescimento Facial: Uma Revisão Integrativa / Use of rich Plasma on platelets in Facial Rejuvenation: An Integrating Review

A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment

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