2017
DOI: 10.1016/j.cmet.2016.11.001
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Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis

Abstract: Most of the biological understanding of mechanisms underlying coronary artery disease (CAD) derives from studies of mouse models. The identification of multiple CAD loci and strong candidate genes in large human genome-wide association studies (GWAS) presented an opportunity to examine the relevance of mouse models for the human disease. We comprehensively reviewed the mouse literature, including 827 literature-derived genes, and compared it to human data. First, we observed striking concordance of risk factor… Show more

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Cited by 177 publications
(146 citation statements)
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References 148 publications
(158 reference statements)
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“…Occurrence of atherosclerotic lesions in subordinate mice represents an unexpected and exceptional outcome (von Scheidt et al., 2017) suggesting that increased risk of cardiovascular disease is a critical pathogenic mechanism in relation to subordination stress‐induced decrease in lifespan.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Occurrence of atherosclerotic lesions in subordinate mice represents an unexpected and exceptional outcome (von Scheidt et al., 2017) suggesting that increased risk of cardiovascular disease is a critical pathogenic mechanism in relation to subordination stress‐induced decrease in lifespan.…”
Section: Resultsmentioning
confidence: 99%
“…Atherosclerosis represents an unexpected outcome in a species where this cardiovascular disease only develops in genetically predisposed strains under severe atherogenic dietary regimens (von Scheidt et al., 2017). Current and previous data point to hyperglycemia, insulin resistance, lipotoxicity, chronic low grade inflammation, dyslipidemia, and increased catecholamines and glucocorticoids as likely contributors to the development of early‐stage atherosclerosis in subordinate mice (Bartolomucci, 2007; Du et al., 2016; Heidt et al., 2014; Najafi et al., 2013; Razzoli, Karsten, Yoder, Bartolomucci & Engeland, 2014; Sanghez et al., 2013, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…The similarities of mouse genes to those identified as promoting risk in human genome-wide association studies enhance the potential to extrapolate findings in mouse models to the human disease. 12,13 Also, mousebased models have been particularly useful for elucidating effects of individual genes on atherosclerosis, with subsequent confirmation of human relevance in many instances. Salient examples include the elucidation of genes regulating triglyceride-rich lipoprotein metabolism in mice and their impact on atherosclerosis, such as apoCIII 14 and apoAV.…”
Section: Insights Provided By Animal Modelsmentioning
confidence: 99%
“…A recent review comparing the results of human GWAS studies and genetic studies of atherosclerosis in mouse models demonstrated significant overlap in the risk factors for atherogenesis and genes influencing atherosclerosis in both species [11]**.…”
Section: Introductionmentioning
confidence: 99%