Applications of 3D printing in tumor treatment

Li, Jiante; Liang, Danna; Chen, Xiang; Sun, Weijian; Shen, Xian

doi:10.1016/j.bmt.2023.03.002

Cited by 17 publications

(2 citation statements)

References 142 publications

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“…The emergence of additive manufacturing, most commonly known as 3D printing, has opened new possibilities in different scientific fields (e.g., [ 1 , 2 , 3 , 4 , 5 , 6 ]), including medicine (e.g., [ 7 , 8 , 9 , 10 , 11 , 12 ]). The 3D printing approach enables the building of a three-dimensional geometrical object layer-by-layer, guided by computer-aided design (CAD)/computer-aided manufacturing (CAM) software [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.

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Section: Introductionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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“…3D printing technologies are gaining momentum in a variety of industries, ICADME-2023 Journal of Physics: Conference Series 2643 (2023) 012006 IOP Publishing doi:10.1088/1742-6596/2643/1/012006 2 including aerospace and machine manufacturing. Numerous facets of society have benefited from the use of additive manufacturing, including manufacturing, aerospace, automotive, electronics, robotics, healthcare, prosthetics, fashion, general commerce, food processing and education [1][2][3]. Different medium or printer inks are used by different types of additive manufacturing techniques.…”

Section: Introductionmentioning

confidence: 99%

Development of new formulation for soft material in paste extrusion-based 3D Printer

Khan,

Baharudin,

Tajul

2023

J. Phys.: Conf. Ser.

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Fused Deposition Modelling is a form of additive manufacturing where solid filament is heated into molten state and deposited onto a heating platform to create three-dimensional objects layer-by-layer. Since heating and cooling processes are involved in Fused Deposition Modelling (FDM), this restricts the use of thermoplastic polymers such Room Temperature Vulcanizing (RTV) silicones and gels. Others concern are with the right rheological properties for extrusion and the ability to provide desired mechanical qualities upon quick solidification. To develop a suitable silicone printing technology, it is crucial to understand the silicone polymerization mechanism in terms of its rheological and mechanical characteristics. Due to the numerous factors that can influence silicone paste mixtures, this study utilized the Taguchi method to design experiments, optimize factors, and predict properties, thereby avoiding extensive and resource-intensive experimental work. The study specifically considered the factors of curing method, mass ratio of silicone thinner, and fumed-silica in the silicone paste formulation. Among the 9 samples generated through the Taguchi method, only one sample demonstrated favourable results in terms of mechanical properties and the curing process, with a mixture ratio of base silicone, silicone thinner, and fumed-silica at 15g, <1g, 0.1g; respectively. However, further investigation into the fixed amount of silicone and fumed silica in the selected mixture ratio indicate that the amount of silicone thinner must be less than 1g or can be omitted as the silicone paste can be used as printing ink for the extruder. The shore hardness testing for the silicone samples revealed with zero percent silicone thinner exhibited a hardness value of 21.5 HA (Shore A) while the sample obtained less than 1g displayed a significantly lower hardness value of 10.5 HA. These findings indicate that the addition of silicone thinner in the silicone paste formulation, as optimized through the Taguchi method, contributed to a reduction in the hardness of the material for shore A scale. This suggests that the presence of silicone thinner affects the elasticity and flexibility of the silicone paste, resulting in a lower Shore hardness value. The discrepancy in hardness values between the samples further highlights the significance of formulation optimization to achieve desired material properties for silicone paste-based applications in 3D printing.

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3D Biofabrication of Microporous Hydrogels for Tissue Engineering

Liu,

Wu,

Luo

et al. 2024

Adv Healthcare Materials

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Microporous hydrogels have been utilized in an unprecedented manner in the last few decades, combining materials science, biology, and medicine. Their microporous structure makes them suitable for wide applications, especially as cell carriers in tissue engineering and regenerative medicine. Microporous hydrogel scaffolds provide spatial and platform support for cell growth and proliferation, which can promote cell growth, migration, and differentiation, influencing tissue repair and regeneration. This review gives an overview of recent developments in the fabrication techniques and applications of microporous hydrogels. The fabrication of microporous hydrogels can be classified into two distinct categories: fabrication of non‐injectable microporous hydrogels including freeze‐drying microporous method, two‐phase sacrificial strategy, 3D biofabrication technology, etc., and fabrication of injectable microporous hydrogels mainly including microgel assembly. Then, the biomedical applications of microporous hydrogels in cell carriers for tissue engineering, including but not limited to bone regeneration, nerve regeneration, vascular regeneration, and muscle regeneration are emphasized. Additionally, the ongoing and foreseeable applications and current limitations of microporous hydrogels in biomedical engineering are illustrated. Through stimulating innovative ideas, the present review paves new avenues for expanding the application of microporous hydrogels in tissue engineering.

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Applications of 3D printing in tumor treatment

Cited by 17 publications

References 142 publications

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Development of new formulation for soft material in paste extrusion-based 3D Printer

3D Biofabrication of Microporous Hydrogels for Tissue Engineering

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