Applications of advanced diffusion MRI in early brain development: a comprehensive review

DiPiero, Marissa; Rodrigues, Patrik Goncalves; Gromala, Alyssa; Dean, Douglas C.

doi:10.1007/s00429-022-02605-8

Cited by 11 publications

(6 citation statements)

References 221 publications

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“…NODDI allows for the compartmentalization of the diffusion imaging signal in intra- (i.e., axons and dendrites) and extra- (i.e., glia, cerebrospinal fluid) neuritic spaces, leading to estimates of the microstructural complexity of different tissues in the brain [ 131 ]. Notably, NODDI measures have been shown to be more sensitive than standard diffusion tensor imaging measures (e.g., fractional anisotropy) to structural-developmental changes in normative [ 25 , 132 , 133 ] and clinical [ 87 , 88 , 89 , 134 , 135 , 136 , 137 ] samples. Specific NODDI metrics include the free-water isotropic volume fraction (FISO), reflecting the free water volume fraction; the Neurite Density Index (NDI), reflecting the intra-neurite density; and the Orientation Dispersion Index (ODI), reflecting the angular dispersion of neurites.…”

Section: Role Of Neuroimaging In Concussionmentioning

confidence: 99%

“…Neuroimaging techniques, including computed tomography and magnetic resonance imaging, have been widely used to objectively characterize neurodevelopmental changes as they occur throughout the lifespan [ 25 , 26 , 27 , 28 ]. Neuroimaging has also been extensively used to detect brain abnormalities in concussed samples [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Santos

Jia-Richards

Kontos

et al. 2023

IJERPH

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Emotional dysregulation symptoms following a concussion are associated with an increased risk for emotional dysregulation disorders (e.g., depression and anxiety), especially in adolescents. However, predicting the emergence or worsening of emotional dysregulation symptoms after concussion and the extent to which this predates the onset of subsequent psychiatric morbidity after injury remains challenging. Although advanced neuroimaging techniques, such as functional magnetic resonance imaging and diffusion magnetic resonance imaging, have been used to detect and monitor concussion-related brain abnormalities in research settings, their clinical utility remains limited. In this narrative review, we have performed a comprehensive search of the available literature regarding emotional regulation, adolescent concussion, and advanced neuroimaging techniques in electronic databases (PubMed, Scopus, and Google Scholar). We highlight clinical evidence showing the heightened susceptibility of adolescents to experiencing emotional dysregulation symptoms following a concussion. Furthermore, we describe and provide empirical support for widely used magnetic resonance imaging modalities (i.e., functional and diffusion imaging), which are utilized to detect abnormalities in circuits responsible for emotional regulation. Additionally, we assess how these abnormalities relate to the emotional dysregulation symptoms often reported by adolescents post-injury. Yet, it remains to be determined if a progression of concussion-related abnormalities exists, especially in brain regions that undergo significant developmental changes during adolescence. We conclude that neuroimaging techniques hold potential as clinically useful tools for predicting and, ultimately, monitoring the treatment response to emotional dysregulation in adolescents following a concussion.

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Section: Role Of Neuroimaging In Concussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Santos

Jia-Richards

Kontos

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…Taken together, diffusion MRI metrics have been shown to be sensitive to brain microstructural changes across the lifespan, from early brain development ( 47 ) to aging and neurodegenerative conditions ( 37 , 48 ). For example, diffusion MRI metrics have been shown to be sensitive to glial activation, edema, axonal swelling, and changes in axonal myelination ( 49 ).…”

Section: Introductionmentioning

confidence: 99%

Purpose in life as a resilience factor for brain health: diffusion MRI findings from the Midlife in the U.S. study

Nair,

Adluru,

Finley

et al. 2024

Front. Psychiatry

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IntroductionA greater sense of purpose in life is associated with several health benefits relevant for active aging, but the mechanisms remain unclear. We evaluated if purpose in life was associated with indices of brain health.MethodsWe examined data from the Midlife in the United States (MIDUS) Neuroscience Project. Diffusion weighted magnetic resonance imaging data (n=138; mean age 65.2 years, age range 48-95; 80 females; 37 black, indigenous, and people of color) were used to estimate microstructural indices of brain health such as axonal density, and axonal orientation. The seven-item purpose in life scale was used. Permutation analysis of linear models was used to examine associations between purpose in life scores and the diffusion metrics in white matter and in the bilateral hippocampus, adjusting for age, sex, education, and race.Results and discussionGreater sense of purpose in life was associated with brain microstructural features consistent with better brain health. Positive associations were found in both white matter and the right hippocampus, where multiple convergent associations were detected. The hippocampus is a brain structure involved in learning and memory that is vulnerable to stress but retains the capacity to grow and adapt through old age. Our findings suggest pathways through which an enhanced sense of purpose in life may contribute to better brain health and promote healthy aging. Since purpose in life is known to decline with age, interventions and policy changes that facilitate a greater sense of purpose may extend and improve the brain health of individuals and thus improve public health.

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“…In this light, magnetic resonance imaging (MRI) plays an unquestionable role in the evaluation of patients with neurodegenerative disorders, including SPAX patients, not only for clinical purposes but also by providing quantitative, reliable, and in vivo information on neuronal damage [5,6] during the disease course. Among all the sequences available, diffusion MRI (dMRI) is a quantitative technique able to capture subtle but meaningful changes occurring in several conditions, from neurodevelopmental to neurodegenerative, as well as psychiatric or neuroinflammatory disorders [7][8][9][10][11][12]. This method, sensitive to water diffusion characteristics in brain tissue, represent a marker of white matter (WM) microstructural integrity [13], with different parameters that can be extracted from a single sequence but that can provide simultaneously complementary information about neuronal integrity [14,15].…”

Section: Introductionmentioning

confidence: 99%

An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study

Scaravilli,

Gabusi,

Mari

et al. 2024

J Neurol

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Background Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) and Spastic Paraplegia Type 7 (SPG7) are paradigmatic spastic ataxias (SPAX) with suggested white matter (WM) involvement. Aim of this work was to thoroughly disentangle the degree of WM involvement in these conditions, evaluating both macrostructure and microstructure via the analysis of diffusion MRI (dMRI) data. Material and methods In this multi-center prospective study, ARSACS and SPG7 patients and Healthy Controls (HC) were enrolled, all undergoing a standardized dMRI protocol and a clinimetrics evaluation including the Scale for the Assessment and Rating of Ataxia (SARA). Differences in terms of WM volume or global microstructural WM metrics were probed, as well as the possible occurrence of a spatially defined microstructural WM involvement via voxel-wise analyses, and its correlation with patients’ clinical status. Results Data of 37 ARSACS (M/F = 21/16; 33.4 ± 12.4 years), 37 SPG7 (M/F = 24/13; 55.7 ± 10.7 years), and 29 HC (M/F = 13/16; 42.1 ± 17.2 years) were analyzed. While in SPG7, only a mild mean microstructural damage was found compared to HC, ARSACS patients present a severe WM involvement, with a reduced global volume (p < 0.001), an alteration of all microstructural metrics (all with p < 0.001), without a spatially defined pattern of damage but with a prominent involvement of commissural fibers. Finally, in ARSACS, a correlation between microstructural damage and SARA scores was found (p = 0.004). Conclusion In ARSACS, but not SPG7 patients, we observed a complex and multi-faced involvement of brain WM, with a clinically meaningful widespread loss of axonal and dendritic integrity, secondary demyelination and, overall, a reduction in cellularity and volume.

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Applications of advanced diffusion MRI in early brain development: a comprehensive review

Cited by 11 publications

References 221 publications

Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Purpose in life as a resilience factor for brain health: diffusion MRI findings from the Midlife in the U.S. study

An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study

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