Applications of advanced materials in the pretreatment and rapid detection of small molecules in foods: A review

Recent Progress of Electrochemical Aptasensors toward AFB1 Detection (2018–2023)

“…Solid-phase microextraction, magnetic solid-phase extraction, dispersive solid-phase extraction, and matrix solid-phase dispersion extraction can overcome the disadvantages of traditional methods. Materials with efficient adsorption properties, high and easily tailored surface areas, such as metallic organic frameworks (MOFs), covalent organic frameworks (COFs), molecularly imprinted polymers (MIPs), carbon-based nanomaterials, and aerogels, become of interest in the pretreatment step of foodstuffs [72]. MOFs, as emerging advanced materials, may serve both as a pretreatment tool and electrode surface modifier [73].…”

“…Advanced and efficient sample pretreatment methods for electrochemical sensing are still a major requirement nowadays. Recent reviews [72,78] report advanced methods for food sample preparation, but, generally, the analyte determination is further performed via conventional chromatographic methods. Sufficient enrichment of and efficient reduction in the matrix interference must be achieved to improve the accuracy and sensitivity of the electrochemical assays to address the food analysis requirements.…”

Covalent organic frameworks-based materials for antibiotics fluorescence detection

“…The development of rapid detection technology of trace small molecules is the development goal of food field detection. In recent years, emerging advanced materials with their unique physical and chemical properties have been gradually used for sample pretreatment and rapid detection of trace small molecules in food, with great application potential [ 32 ]. Antibiotics serve as main medicines to help people to counter the infection of numerous bacteria [ 33 ].…”

Harnessing Small-Molecule Analyte Detection in Complex Media: Combining Molecularly Imprinted Polymers, Electrolytic Transistors, and Machine Learning

“…Detecting small-molecule analytes is pivotal in various fields of science and technology, including quality control of food and beverages, environmental monitoring, and clinical diagnostics. − These analytes are low-molecular-weight compounds (typically <1 kDa), displaying a wide range of chemical structures, which serve as food additives, drugs and pharmaceutical products, pesticides, pollutants, toxins, metabolites, etc. , Small molecules are also important biomarkers of various diseases and can be found in physiological fluids such as urine, blood, and saliva. Their precise detection and quantification are essential for biomedical research and personalized medicine, especially for the early detection of diseases. , …”