Applications of advanced neuro-behavioral analysis strategies in aquatic ecotoxicology

Bownik, Adam; Wlodkowic, Donald

doi:10.1016/j.scitotenv.2021.145577

Cited by 32 publications

(48 citation statements)

References 162 publications

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“…From a mechanistic perspective, an increasing number of methods in molecular neurotoxicology are now available for uncovering drivers of pollutant‐induced behavioural changes (reviewed in Bownik & Wlodkowic, 2021). These methods range from transcriptomics (i.e.…”

Section: Tools and Technologies For Advancing Behavioural Ecotoxicologymentioning

confidence: 99%

“…analysis of proteins) and enzymatic assays, metabolomics (i.e. analysis of chemical processes involving metabolites in cells and tissues), and examination of sub‐cellular processes such as programmed cell death (Bownik & Wlodkowic, 2021). An important recent advance that promises to increase mechanistic understanding in behavioural ecotoxicology is large‐scale neurotransmitter profiling, enabled by the above‐mentioned rapid developments in analytical chemistry (see Section II.1).…”

Section: Tools and Technologies For Advancing Behavioural Ecotoxicologymentioning

confidence: 99%

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Frontiers in quantifying wildlife behavioural responses to chemical pollution

et al. 2022

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Animal behaviour is remarkably sensitive to disruption by chemical pollution, with widespread implications for ecological and evolutionary processes in contaminated wildlife populations. However, conventional approaches applied to study the impacts of chemical pollutants on wildlife behaviour seldom address the complexity of natural environments in which contamination occurs. The aim of this review is to guide the rapidly developing field of behavioural ecotoxicology towards increased environmental realism, ecological complexity, and mechanistic understanding. We identify research areas in ecology that to date have been largely overlooked within behavioural ecotoxicology but which promise to yield valuable insights, including within-and among-individual variation, social networks and collective behaviour, and multi-stressor interactions. Further, we feature methodological and technological innovations that enable the collection of data on pollutant-induced behavioural changes at an unprecedented resolution and scale in the laboratory and the field. In an era of rapid environmental change, there is an urgent need to advance our understanding of the real-world impacts of chemical pollution on wildlife behaviour. This review therefore provides a roadmap of the major outstanding questions in behavioural ecotoxicology and highlights the need for increased cross-talk with other disciplines in order to find the answers.

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Section: Tools and Technologies For Advancing Behavioural Ecotoxicologymentioning

confidence: 99%

Section: Tools and Technologies For Advancing Behavioural Ecotoxicologymentioning

confidence: 99%

Frontiers in quantifying wildlife behavioural responses to chemical pollution

et al. 2022

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“…Behavioral response with sublethal pollutant concentrations were reported to be fast and sensitive biomarkers for water quality, ecotoxicological and chemical risk assessments ( Hellou, 2011 ; Melvin and Wilson, 2013 ; Pyle and Ford, 2017 ; Legradi et al, 2018 ; Xia et al, 2018 ). Some behavioral outcomes have been measured in contaminant-exposed fish, including swimming speeds, startle responses, prey capture abilities, learning, and memory, which related to the probability of escaping a predator or capturing prey for feeding ( Legradi et al, 2018 ; Bownik and Wlodkowic, 2021 ; Fitzgerald et al, 2021 ). Considering the increasing numbers of environmental contaminants and their unknown neurotoxic potentials, identifying and improving neurotoxicity testing strategies and methods are important for eco-neurotoxicity assessments in the future ( Pyle and Ford, 2017 ; Legradi et al, 2018 ; Xia et al, 2018 ; Fitzgerald et al, 2021 ).…”

Section: Environmental Risk Assessments With Behavioral Monitoringmentioning

confidence: 99%

Fish Behavior as a Neural Proxy to Reveal Physiological States

Horng

Chou

2022

Front. Physiol.

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Behaviors are the integrative outcomes of the nervous system, which senses and responds to the internal physiological status and external stimuli. Teleosts are aquatic organisms which are more easily affected by the surrounding environment compared to terrestrial animals. To date, behavioral tests have been widely used to assess potential environmental risks using fish as model animals. In this review, we summarized recent studies regarding the effects of internal and external stimuli on fish behaviors. We concluded that behaviors reflect environmental and physiological changes, which have possible implications for environmental and physiological assessments.

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“…Behavioral assessment, regarded as a functional endpoint, is an integrative signal representing nervous system status or fitness [ 12 , 13 , 14 ]. Not only are larval zebrafish able to exhibit many different behaviors [ 15 , 16 ] but, analogous to mammalian neurodevelopment, the development of the zebrafish nervous system is guided and influenced by the interplay among brain development and endocrine systems such as the hypothalamus-pituitary-thyroid (HPT) axis [ 17 , 18 , 19 ] and the hypothalamo-pituitary-adrenal (inter-renal in zebrafish) (HPA/HPI) axis (reviewed in [ 20 ]).…”

Section: Introductionmentioning

confidence: 99%

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

Jarema

Hunter

Hill

et al. 2022

Toxics

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With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays. This study evaluated the developmental toxicity and behavioral effects of 61 chemicals in zebrafish (Danio rerio) larvae using a behavioral Light/Dark assay. Larvae (n = 16–24 per concentration) were exposed to each chemical (0.0001–120 μM) during development and locomotor activity was assessed. Approximately half of the chemicals (n = 30) did not show any gross developmental toxicity (i.e., mortality, dysmorphology or non-hatching) at the highest concentration tested. Twelve of the 31 chemicals that did elicit developmental toxicity were toxic at the highest concentration only, and thirteen chemicals were developmentally toxic at concentrations of 10 µM or lower. Eleven chemicals caused behavioral effects; four chemicals (6-aminonicotinamide, cyclophosphamide, paraquat, phenobarbital) altered behavior in the absence of developmental toxicity. In addition to screening a library of chemicals for developmental neurotoxicity, we also compared our findings with previously published results for those chemicals. Our comparison revealed a general lack of standardized reporting of experimental details, and it also helped identify some chemicals that appear to be consistent positives and negatives across multiple laboratories.

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Applications of advanced neuro-behavioral analysis strategies in aquatic ecotoxicology

Cited by 32 publications

References 162 publications

Frontiers in quantifying wildlife behavioural responses to chemical pollution

Frontiers in quantifying wildlife behavioural responses to chemical pollution

Fish Behavior as a Neural Proxy to Reveal Physiological States

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

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