Applications of Antioxidants: A Review

Mehla, Neeti; Chhajer, Aditi Kothari; Kumar, Kanishka; Dahiya, Shefali; Mohindroo, Vanshika

doi:10.1007/978-3-030-78160-6_28

Cited by 3 publications

(2 citation statements)

References 140 publications

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“…In total, there were 139 edges and 1 node presence in the built network. The measured values of degree (11), betweenness (10.5), eccentricity (1), eigen vector (6.88E-31), radiality (29.3853211), and stress (12) have revealed the threshold value of all the measurements, as well as a significant node in the network (Table 5).…”

Section: Graph Theoretical Network Analysismentioning

confidence: 99%

“…Oxidative-stress-responsive genes sensitive to secreted primary antioxidant enzymes against free radicals include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and peroxiredoxins [11]. Conversely, non-enzymatic antioxidants (carotenoids, vitamins A, C, and E, flavonoids, alpha-lipoic acid glutathione) interrupt free-radical chain reactions [12]. In addition, intracellular ROS levels elevated above a certain threshold result in the downregulation of cellular antioxidant pathways and enzyme systems, which, in turn, leads to the development of numerous complications via a variety of molecular targets, including nuclear factor-B (NF-B), nuclear factor E2 (erythroid-derived 2)-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), mitogen-activated protein kinases (MAPKs), and phosphoinositide 3-kinase (PI3K) [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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An In Silico Molecular Modelling-Based Prediction of Potential Keap1 Inhibitors from Hemidesmus indicus (L.) R.Br. against Oxidative-Stress-Induced Diseases

et al. 2023

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The present study investigated the antioxidant potential of aqueous methanolic extracts of Hemidesmus indicus (L.) R.Br., followed by a pharmacoinformatics-based screening of novel Keap1 protein inhibitors. Initially, the antioxidant potential of this plant extract was assessed via antioxidant assays (DPPH, ABTS radical scavenging, and FRAP). Furthermore, 69 phytocompounds in total were derived from this plant using the IMPPAT database, and their three-dimensional structures were obtained from the PubChem database. The chosen 69 phytocompounds were docked against the Kelch–Neh2 complex protein (PDB entry ID: 2flu, resolution 1.50 Å) along with the standard drug (CPUY192018). H. indicus (L.) R.Br. extract (100 µg × mL−1) showed 85 ± 2.917%, 78.783 ± 0.24% of DPPH, ABTS radicals scavenging activity, and 161 ± 4 μg × mol (Fe (II)) g−1 ferric ion reducing power. The three top-scored hits, namely Hemidescine (−11.30 Kcal × mol−1), Beta-Amyrin (−10.00 Kcal × mol−1), and Quercetin (−9.80 Kcal × mol−1), were selected based on their binding affinities. MD simulation studies showed that all the protein–ligand complexes (Keap1–HEM, Keap1–BET, and Keap1–QUE) were highly stable during the entire simulation period, compared with the standard CPUY192018–Keap1 complex. Based on these findings, the three top-scored phytocompounds may be used as significant and safe Keap1 inhibitors, and could potentially be used for the treatment of oxidative-stress-induced health complications.

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Section: Graph Theoretical Network Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An In Silico Molecular Modelling-Based Prediction of Potential Keap1 Inhibitors from Hemidesmus indicus (L.) R.Br. against Oxidative-Stress-Induced Diseases

et al. 2023

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Bioactive dry extract production from Hymenaea courbaril L. bark via spouted bed drying

Souza,

Fregonesi,

Oliveira

2024

Can J Chem Eng

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The work aims to develop and optimize a powdered phytopharmaceutical product from the stem bark of Hymenaea courbaril L. (jatobá) by the spouted bed drying. The study commenced with the extraction of bioactive compounds present in the plant raw material by dynamic maceration using ethanol/water 70% (v/v) at a temperature of 50°C for 60 min, for the ratio stem bark: solvent mass of 1:10 (w/w). The extract quality was assessed by quantifying chemical markers via spectrophotometry (total polyphenols and tannins) and through antioxidant activity by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay. The extractive solution was concentrated, added with drying adjuvant, and submitted to spouted bed drying. Product quality was evaluated by moisture content (Xp), water activity (aW), powder diameter, total polyphenols, and tannins content (PT and TT), and antioxidant activity, expressed as the extract concentration needed to reduce 50% of the DDPH radical (IC50). Spouted bed drying performance was evaluated through the drying yield (REC), product accumulation (Ac), and thermal efficiency (η). The optimal processing conditions were: inlet gas temperature, Tgi: 150°C, the ratio of the mass feed flow rate of the concentrated extract to the evaporation capacity of the dryer, Ws/Wmax: 45%, and the drying gas flow rate relative to minimum spouting, Q/Qms: 1.85. Under these conditions, it is predicted to obtain a dried extract with Xp = 4.9% w/w, PT = 26.0% w/w, REC = 77.7% w/w, η = 44.3%, and Ac = 10% w/w, with adequate values of aW, TT, and high antioxidant activity.

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Fatty acids analysis, antioxidant, antimicrobial and biological activity of essential oil of Skimmia laureola Leaves

Bisht¹,

Bhandari²,

Kandari

et al. 2023

Vegetos

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Applications of Antioxidants: A Review

Cited by 3 publications

References 140 publications

An In Silico Molecular Modelling-Based Prediction of Potential Keap1 Inhibitors from Hemidesmus indicus (L.) R.Br. against Oxidative-Stress-Induced Diseases

An In Silico Molecular Modelling-Based Prediction of Potential Keap1 Inhibitors from Hemidesmus indicus (L.) R.Br. against Oxidative-Stress-Induced Diseases

Bioactive dry extract production from Hymenaea courbaril L. bark via spouted bed drying

Fatty acids analysis, antioxidant, antimicrobial and biological activity of essential oil of Skimmia laureola Leaves

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