Applications of co-axial electrospinning in the biomedical field

Khan, Jahangir; Khan, Asfandyar; Khan, Muhammad Qamar; Khan, Hamza

doi:10.1016/j.nxmate.2024.100138

Next Materials

2024

DOI: 10.1016/j.nxmate.2024.100138

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Applications of co-axial electrospinning in the biomedical field

Jahangir Khan,

Asfandyar Khan,

Muhammad Qamar Khan

et al.

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2024

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Cited by 5 publications

References 150 publications

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High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

Ismail,

Wu,

Khodamoradi

et al. 2024

Adv Eng Mater

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Nanofiber production techniques have become increasingly important due to their wide range of applications. However, the complex design of the setup and difficulty in scaling up to high production rate have limited the industrial applicability of some of the conventional fiber generation techniques such as electrospinning. Herein, the touch spinning method is scaled up for nanofiber production using a simple rotating drawing setup with polymers that are relevant for biomedical applications such as polyethylene oxide and gelatin. The process is amenable to use of benign solvent such as water and production of a wide variety of submicron‐scale gelatin‐based nanofibers at a high throughput (≈2.45 g hr−1 with the single channel flow), which is an order of magnitude higher than those produced by other fiber generation methods is shown. The parametric study indicates that the fiber production process can be tuned at a desired rate without sacrificing the fiber quality by simply altering the number of drawing rods, the size of the rotating disk, and the number of solution flow supply channels. The utility of this technique for different biomedical applications such as cell culture and air filtration applications is also demonstrated.

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High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

Ismail,

Wu,

Khodamoradi

et al. 2024

Adv Eng Mater

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Curcumin‐Loaded Co‐Axial Electrospun Chitosan/Polyvinyl Alcohol/Calcium Chloride Nanofibrous Membranes for Wound Healing Enhancement

Cao‐Luu,

Luong,

Nguyen

et al. 2024

ChemistrySelect

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Nanofibrous membranes were developed by combining chitosan (CS), polyvinyl alcohol (PVA), and calcium chloride (CC) to incorporate curcumin (CCM) through a co‐axial electro‐spinning method to improve CCM bioavailability. The optimal parameters were PVA/CS ratio of 7:3 v/v, PVA/CCM ratio of 8:2 v/v, CC amount of 0.5 g, fiber collection distance of 15 cm, voltage value of 18 kV, and injection flow of 0.1 mL/h (both core and shell layer). The prepared PVA/CCM@CS/PVA/CC nanofiber showed smooth surfaces and uniform bead‐free morphology with core‐shell structure. The average fiber diameter was 301.55 ± 76.77 nm with a narrow distribution. Using the Korsmeyer‐Peppas kinetic release model, the nanofiber membrane effectively released ∼85% CCM at pH 7.4 over 96 h via Fickian diffusion transport mechanism. In vitro antibacterial tests demonstrated that the membrane was efficient against both Gram‐positive (Staphylococcus aureus) and Gram‐negative (Pseudomonas aeruginosa) bacteria. When compared to free CCM, the membrane improved cell survival due to its nontoxic and cytobiocompatible features. In vivo tests found that the membrane significantly improved healing in incised‐wound rats, reducing inflammation, fibroblast proliferation, and collagen deposition. These findings indicate that the novel PVA/CCM@CS/PVA/CC nanofiber membrane, which has numerous biological functions, could be a promising candidate for wound dressing therapeutic applications.

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Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Yu,

Gong,

Zhou

et al. 2024

WIREs Nanomed Nanobiotechnol

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The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro‐/nano‐particles, and beads‐on‐a‐string hybrids. They can be further divided into different kinds of sub‐shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH‐sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Applications of co-axial electrospinning in the biomedical field

Cited by 5 publications

References 150 publications

High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

Curcumin‐Loaded Co‐Axial Electrospun Chitosan/Polyvinyl Alcohol/Calcium Chloride Nanofibrous Membranes for Wound Healing Enhancement

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

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