Applications of Cold Atmospheric Pressure Plasma in Dentistry

Borges, Aline Chiodi; Kostov, K. G.; Pessoa, Rodrigo Sávio; Abreu, Geraldo M.A. de; Lima, Gabriela de Morais Gouvêa; Figueira, Leandro Wagner; Koga‐Ito, Cristiane Yumi

doi:10.3390/app11051975

Cited by 55 publications

(48 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The review of literature thus reveals that non-thermal plasma is an effective method of sterilization of dental instruments as well as various dental surfaces because of its potent bactericidal properties. When we compare NTP with conventional sterilization protocols, it has been found to not only be more efficient but also a much faster, thorough alternative [ 48 ]. The fact that the same method may be used for a variety of instruments ranging from plastics, glasses, to metal and more, eliminates the need to have multiple cumbersome sterilizations and disinfection methods and equipment, thus saving time and investment.…”

Section: Application Of Ntp In Dentistrymentioning

confidence: 99%

Aurora Borealis in dentistry: The applications of cold plasma in biomedicine

Lata

Chakravorty

Mitra

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

Plasma is regularly alluded to as the fourth form of matter. Its bounty presence in nature along with its potential antibacterial properties has made it a widely utilized disinfectant in clinical sciences. Thermal plasma and non-thermal (or cold atmospheric) plasma (NTP) are two types of plasma. Atoms and heavy particles are both available at the same temperature in thermal plasma. Cold atmospheric plasma (CAP) is intended to be non-thermal since its electrons are hotter than the heavier particles at ambient temperature. Direct barrier discharge (DBD), atmospheric plasma pressure jet (APPJ), etc. methods can be used to produce plasma, however, all follow a basic concept in their generation. This review focuses on the anticipated uses of cold atmospheric plasma in dentistry, such as its effectiveness in sterilizing dental instruments by eradicating bacteria, its advantage in dental cavity decontamination over conventional methods, root canal disinfection, its effects on tooth whitening, the benefits of plasma treatment on the success of dental implant placement, and so forth. Moreover, the limitations and probable solutions has also been anticipated. These conceivable outcomes thus have proclaimed the improvement of more up-to-date gadgets, for example, the plasma needle and plasma pen, which are efficient in treating the small areas like root canal bleaching, biofilm disruption, requiring treatment in dentistry.

show abstract

Section: Application Of Ntp In Dentistrymentioning

confidence: 99%

Aurora Borealis in dentistry: The applications of cold plasma in biomedicine

Lata

Chakravorty

Mitra

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

show abstract

“…Although there are many studies describing the interaction of plasma and biological organisms, there is little research that assesses the in vivo toxicity of CAP or PAM, particularly over the long-term. Various articles report levels and mechanisms of wanted direct or indirect toxicity against microbial cells and viruses [48][49][50][51][52], algal cells [53], and various tumor cell lines [54][55][56][57][58][59][60][61][62]. Some studies report a lack of cytotoxicity on normal cells [63] others, on the contrary, report the presence of cytotoxicity (that can be dose dependent) [60][61][62][64][65][66].…”

Section: Introductionmentioning

confidence: 99%

“…Cytotoxicity mechanisms include damage to cell walls, cell membranes, DNA, enzymes and other proteins [50,51,54]. The mechanisms are diverse but they all seem to be caused by the generated RONS.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, a surplus of exogenous RONS can have a detrimental effect on the health of various biological organisms, not only by inducing oxidative stress, but also by disturbing the delicate balance of the complex network of intracellular biochemical pathways [61,[71][72][73]. Some authors even report a certain level of selective toxicity against procaryotic cells (bacteria), compared to eucaryotic cells, because the later have protective mechanisms against RONS [54,74].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toxicity Assessment of Long-Term Exposure to Non-Thermal Plasma Activated Water in Mice

Nastasa

Pasca

Mălăncuș

et al. 2021

IJMS

View full text Add to dashboard Cite

Non-thermal plasma activated water (PAW) has recently emerged as a powerful antimicrobial agent. Despite numerous potential bio-medical applications, studies concerning toxicity in live animals, especially after long-term exposure, are scarce. Our study aimed to assess the effects of long-term watering with PAW on the health of CD1 mice. PAW was prepared from distilled water with a GlidArc reactor according to a previously published protocol. The pH was 2.78. The mice received PAW (experimental group) or tap water (control group) daily for 90 days as the sole water source. After 90 days, the following investigations were performed on the euthanatized animals: gross necropsy, teeth mineral composition, histopathology, immunohistochemistry, hematology, blood biochemistry, methemoglobin level and cytokine profile. Mice tolerated PAW very well and no adverse effects were observed during the entire period of the experiment. Histopathological examination of the organs and tissues did not reveal any structural changes. Moreover, the expression of proliferation markers PCNA and Ki67 has not been identified in the epithelium of the upper digestive tract, indicating the absence of any pre- or neoplastic transformations. The results of our study demonstrated that long-term exposure to PAW caused no toxic effects and could be used as oral antiseptic solution in dental medicine.

show abstract

“…Here, we also merge ROS and RNS to call them RONS. The cytotoxicity effects of these species contribute to biomedical treatments [9][10][11][12], specifically in cancer therapies [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Transferred Cold Atmospheric Plasma Treatment on Melanoma Skin Cancer Cells with/without Catalase Enzyme In Vitro

et al. 2021

View full text Add to dashboard Cite

Cold atmospheric plasma (CAP) is a promising tool to overcome certain cancerous and precancerous conditions in dermatology. A scheme of transferred CAP was first developed to treat melanoma (B16F10) skin cancer cells as well as non-malignant (L929) cells in vitro. CAP was transferred using a silicone tube with a jet system that was developed and was assessed as to whether it could generate reactive oxygen and nitrogen species (RONS) at near-room temperature. The transferred CAP was characterized electrically and spectroscopically. Biological data showed that the transferred CAP killed cancer cells but not non-malignant (L929) cells. Plasma treatment was effective with a time duration of 30 s, whereas non-malignant (L929) cells were less damaged during plasma treatment. In addition, catalase (CAT) enzyme was applied to neutralize and detoxify the RONS generated by the transferred CAP. These findings suggest that transferred CAP can be considered a melanoma cancer therapy.

show abstract

Applications of Cold Atmospheric Pressure Plasma in Dentistry

Cited by 55 publications

References 139 publications

Aurora Borealis in dentistry: The applications of cold plasma in biomedicine

Aurora Borealis in dentistry: The applications of cold plasma in biomedicine

Toxicity Assessment of Long-Term Exposure to Non-Thermal Plasma Activated Water in Mice

Transferred Cold Atmospheric Plasma Treatment on Melanoma Skin Cancer Cells with/without Catalase Enzyme In Vitro

Contact Info

Product

Resources

About