Applications of Colon Capsule Endoscopy

Pasha, Shabana F.

doi:10.1007/s11894-018-0628-7

Cited by 25 publications

(19 citation statements)

References 37 publications

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“…However, this previous study did not focus on the performance of CCE as a screening tool in a screening population. Participation rate is one of the key performance indicators in a population-based screening program [1,3]. The overall participation in 21 European countries was 49.5 % in countries using FIT-based screening, while the desirable uptake according to the European guidelines is > 65 % [1].…”

Section: Discussionmentioning

confidence: 99%

“…Most European countries use a fecal immunochemical test (FIT) followed by colonoscopy in individuals with a positive FIT result [2]. However, the performance of this screening strategy seems to be hampered by low participation rates for colonoscopy [3]. This could be due to the fact that colonoscopy is perceived as an invasive and painful procedure and the fact that it requires some form of sedation [4].…”

Section: Introductionmentioning

confidence: 99%

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Colon capsule endoscopy in colorectal cancer screening: a systematic review

et al. 2021

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Introduction Primary colonoscopy and fecal immunochemical test (FIT) are the most commonly used colorectal cancer (CRC) screening modalities. Colon capsule endoscopy (CCE) might be an alternative. Data on the performance of CCE as a CRC screening tool in a screening population remain scarce. This is the first systematic review to provide an overview of the applicability of CCE as a CRC screening tool. Methods A systematic search was conducted of literature published up to September 2020. Studies reporting on CRC screening by second-generation CCE in an average-risk screening population were included. Results 582 studies were identified and 13 were included, comprising 2485 patients. Eight studies used CCE as a filter test after a positive FIT result and five studies used CCE for primary screening. The polyp detection rate of CCE was 24 % – 74 %. For polyps > 6 mm, sensitivity of CCE was 79 % – 96 % and specificity was 66 % – 97 %. For polyps ≥ 10 mm, sensitivity of CCE was 84 % – 97 %, which was superior to computed tomographic colonography (CTC). The CRC detection rate for completed CCEs was 93 % (25/27). Bowel preparation was adequate in 70 % – 92 % of examinations, and completion rates varied from 57 % to 92 %, depending on the booster used. No CCE-related complications were described. Conclusion CCE appeared to be a safe and effective tool for the detection of CRC and polyps in a screening setting. Accuracy was comparable to colonoscopy and superior to CTC, making CCE a good alternative to colonoscopy in CRC screening programs, although completion rates require improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Colon capsule endoscopy in colorectal cancer screening: a systematic review

et al. 2021

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“…In 2014, capsule colonoscopy was approved by the United States FDA to detect colon polyp only for patients with incomplete colonoscopy [14]. Methylated SEPT9 DNA is shed into the blood from colon cancer and it can be detected by polymerase chain reaction (PCR) in the blood.…”

Section: Screening Programsmentioning

confidence: 99%

Colon Cancer: A Clinician’s Perspective in 2019

2020

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Colon cancer is a common preventable cancer. With the adoption of widespread colon cancer screening in the developed countries, the incidence and mortality of colon cancer have decreased in the targeted population. But unfortunately, the incidence and mortality of colorectal cancer (CRC) have been increasing over the last 25 years in the young adults below the age of 50. There is disparity in benefit, i.e. reduction in risk of death between right-sided and left-sided colon cancer by screening colonoscopy. The reason could be multifactorial and various measures have been taken to decrease this disparity. Although most of the screened populations are average risk individuals, a minority of the population have various risk factors for developing colon cancer and need to follow specific colon cancer screening guidelines. Gene mutations (adenomatous polyposis coli (APC), deleted in colon cancer (DCC), K-ras, p53, B-Raf proto-oncogene serine/threonine kinase (BRAF), mismatch repair genes) and microsatellite instability lead to the development of colon cancer. Although various non-invasive methods of colon cancer screening are now available, colonoscopy remains the gold standard of colon cancer screening and adenoma detection rate is now being used as the quality metrics in screening colonoscopy. Although Multi-Society Task Force (MSTF) and American College of Physicians (ACP) recommend initiating screening colonoscopy at age 50 years in all individuals except African Americans who should begin screening colonoscopy at age 45 years, the American Cancer Society (ACS) recommends initiating screening colonoscopy at age 45 years in all individuals irrespective of race and ethnicity. Low-volume split-dose prep has been found to be as effective as high-volume split-dose prep and more tolerable to patients with increased compliance. Boston bowel preparation scale is recommended to measure the quality of colon cleansing. CRC is curative if it is diagnosed at an early stage but various palliative treatment options (endoscopic, oncologic and surgical) are available in advanced stages of this cancer. Adequate number of lymph node assessment during surgery is essential in accurate staging of CRC. Checkpoint inhibitors have been found to have dramatic response and durable clinical benefit in dMMR/MSI-H metastatic CRC. Different genetic and immune-oncologic research trials are ongoing for early detection and better management of CRC.

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“…Diagnosis and management of small bowel polyp is complex which requires capsule endoscopy and MR enterography. 6,7 Occasionally intraoperative endoscopy and enterotomy is needed for removal of large distal small-bowel polyps. 8 Patient with PJS are at increased chance of developing malignancy 9 hence the require routine screening and surveillance and various protocols have been suggested to monitor stomach, small and large bowel, breasts, testicles, ovaries, uterus, and pancreas by various procedures as frequently as once a year.…”

Section: Discussionmentioning

confidence: 99%