Applications of cryostructures in the chromatographic separation of biomacromolecules

Babanejad, Niloofar; Mfoafo, Kwadwo; Zhang, Ershuai; Omidi, Yadollah; Razeghifard, Reza; Omidian, Hossein

doi:10.1016/j.chroma.2022.463546

Cited by 13 publications

(3 citation statements)

References 181 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transition metal ions, such as Cu(II), Ni(II), Zn(II), and Co(II), which are known as Lewis acids and are considered electron pairs, can coordinate with electron-donating groups (such as N, S, and O) in chelating compounds. The remaining metal coordination zones are normally retained by water molecules [ 25 ]. N-methacryloyl-L-histidine methyl ester (MAH) was developed as an affinity-chelating monomer for the separation of different kinds of analytes by introducing its functional histidine group into the polymeric structure without any ligand leakage [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance

et al. 2022

View full text Add to dashboard Cite

A molecularly designed imprinting method was combined with a gravimetric nanosensor for the real-time detection Cu(II) ions in aqueous solutions without using expensive laboratory devices. Thus, 1:1 and 2:1 mol-ratio-dependent coordination modes between Cu(II), N-methacyloly-L histidine methyl ester (MAH) functional monomer complexes, and their four-fold and six-fold coordinations were calculated by means of density functional theory molecular modeling. Cu(II)-MIP1 and Cu(II)-MIP2 nanoparticles were synthesized in the size range of 80–100 nm and characterized by SEM, AFM and FTIR. Cu(II)-MIP nanoparticles were then conducted to a quartz crystal microbalance sensor for the real-time detection of Cu(II) ions in aqueous solutions. The effects of initial Cu(II) concentration, selectivity, and imprinting efficiency were investigated for the optimization of the nanosensor. Linearity of 99% was obtained in the Cu(II) ion linear concentration range of 0.15–1.57 µM with high sensitivity. The LOD was obtained as 40.7 nM for Cu(II)-MIP2 nanoparticles. The selectivity and the imprinting efficiency of the QCM nanosensor were obtained significantly in the presence of competitive ion samples (Co(II), Ni(II), Zn(II), and Fe(II)). The results are promising for sensing Cu(II) ions as environmental toxicants in water by combining molecularly designed ion-imprinted nanoparticles and a gravimetric sensor.

show abstract

Section: Resultsmentioning

confidence: 99%

Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Cryogels have emerged as highly versatile and promising biomaterials with numerous applications in various biomedical fields [ 1 , 2 , 3 , 4 , 5 , 6 ]. These highly porous interconnected structures possess unique properties such as large, interconnected pores, high surface area, elasticity, and efficient diffusion, making them ideal for pharmaceutical and biomedical applications [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…The potential of cryogels in biomedical applications, including drug delivery, tissue engineering, wound healing, and antibacterial properties, has been extensively explored [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Cryogels enable the creation of macroporous hydrogels with controlled porosity, facilitating enhanced cell penetration and stability in drug delivery and tissue engineering [ 1 , 2 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Cryogels: Advancing Biomaterials for Transformative Biomedical Applications

2023

Self Cite

View full text Add to dashboard Cite

Cryogels, composed of synthetic and natural materials, have emerged as versatile biomaterials with applications in tissue engineering, controlled drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties, such as mechanical strength and release profiles, remains challenging. To advance the field, researchers are exploring advanced manufacturing techniques, biomimetic design, and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise. In vivo evaluation and clinical trials are crucial for safety and efficacy. Overcoming practical challenges, including scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness, is essential. By addressing these challenges, cryogels can transform biomedical applications with innovative biomaterials.

show abstract

Ion-exchange separations of biomacromolecules on grafted and surface-modified polymers

2024

Ion-Exchange Chromatography and Related Techniques

View full text Add to dashboard Cite

Applications of cryostructures in the chromatographic separation of biomacromolecules

Cited by 13 publications

References 181 publications

Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance

Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance

Cryogels: Advancing Biomaterials for Transformative Biomedical Applications

Ion-exchange separations of biomacromolecules on grafted and surface-modified polymers

Contact Info

Product

Resources

About