Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review

Nikzamir, Mohammad; Hanifehpour, Younes; Akbarzadeh, Abolfazl; Panahi, Yunes

doi:10.1007/s10904-021-01925-2

Cited by 94 publications

(37 citation statements)

References 152 publications

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“…Non-lipidic NCs enclose a broad variety of organic and inorganic nanomaterials, a few of which are next highlighted for their recent interest for the enhancement of percutaneous permeation: dendrimers are hyperbranched arborescent spherical NPs that may be composed by either natural (e.g., amino acid- or peptide-based) or artificial (e.g., ethylene glycol-based) dendrons, whose individual structure and tridimensional arrangement in the final dendrimer have great impact on the physical, chemical, and drug loading/release properties of the whole nanosystem [ 89 ]. The biomedical relevance of dendrimers, including for drug delivery, is growing exponentially [ 90 , 91 ], and interest is now falling on topical applications. Latest reports in this regard concern, e.g., use of poly(amidoamine)- or PAMAM-based dendrimers for enhanced skin permeation of the chlorhexidine digluconate antiseptic [ 92 ], or dermal delivery and follicular targeting of the antiacneic agent adapalene [ 93 ].…”

Section: Overview Of Current Methods For Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

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Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

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Section: Overview Of Current Methods For Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…Like various other nanocarriers, dendrimer‐based nanocarriers can also be stimuli‐responsive while some of them can be designed to undergo biodegradation to release drugs follow similar mechanistic pathways as summarized in Figure 11 . [ 244 , 245 ]…”

Section: Various Polymeric Nanocarriers For Drug Deliverymentioning

confidence: 99%

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

2022

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Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organelles. Variety of natural sources, availability of different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, and biodegradability have presented polymers as one of the most desired materials for nanocarrier design. Recent innovative concepts and advances in PNC-associated nanotechnology are providing unprecedented opportunities to engineer nanocarriers and their functions. The efficiency of therapeutic loading has got considerably increased. Structural design-based varieties of PNCs are widely employed for the delivery of small therapeutic molecules to genes, and proteins. PNCs have gained ever-increasing attention and certainly paves the way to develop advanced nanomedicines. This article presents a comprehensive investigation of structural design-based varieties of PNCs and the influences of their physicochemical properties on drug delivery profiles with perspectives highlighting the inevitability of incorporating both the multi-stimuli-responsive and multi-drug delivery properties in a single carrier to design intelligent PNCs as new and emerging research directions in this rapidly developing area.

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“…Poly-(amidoamine) (PAMAM) and polypropylenimines (PPI) are the most dendrimers polymers evaluated for their efficient drug delivery due to the availability of a great density of amine groups on their surface Also, the dendrimers structure determines the number and type of bioactive molecule in a DDS, which can be covalently conjugated to the dendrimer terminal groups or enclosed within the core by hydrogen bonding, electrostatic interaction, or hydrophobic linkages (Nikzamir et al, 2021).…”

Section: Dendrimersmentioning

confidence: 99%

Microemulsion Based Nanostructures for Drug Delivery

Arredondo-Ochoa

Silva-Martínez

2022

Front. Nanotechnol.

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Most of the active pharmaceutical compounds are often prone to display low bioavailability and biological degradation represents an important drawback. Due to the above, the development of a drug delivery system (DDS) that enables the introduction of a pharmaceutical compound through the body to achieve a therapeutic effect in a controlled manner is an expanding application. Henceforth, new strategies have been developed to control several parameters considered essential for enhancing delivery of drugs. Nanostructure synthesis by microemulsions (ME) consist of enclosing a substance within a wall material at the nanoscale level, allowing to control the size and surface area of the resulting particle. This nanotechnology has shown the importance on targeted drug delivery to improve their stability by protecting a bioactive compound from an adverse environment, enhanced bioavailability as well as controlled release. Thus, a lower dose administration could be achieved by minimizing systemic side effects and decreasing toxicity. This review will focus on describing the different biocompatible nanostructures synthesized by ME as controlled DDS for therapeutic purposes.

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Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review

Cited by 94 publications

References 152 publications

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Microemulsion Based Nanostructures for Drug Delivery

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