Applications of differential scanning calorimetry in pharmaceutical analysis

Reubke, Renate; Mollica, Joseph A.

doi:10.1002/jps.2600560706

Cited by 41 publications

(9 citation statements)

References 8 publications

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“…The thermograms generated by the samples were reproduced on paper of a uniform thickness, and each area was carefully cut out and weighed (28). The stearic acid calibration coefficient, 0.0641969 (0.0642).…”

Section: Experimental'mentioning

confidence: 99%

“…is the average of the determinations from each sample calculated according to the following equation: Because the instrument does not provide readings in Celsius degrees, the fusion endotherms of stearic acid were used to determine a calibration constant for temperature correction. The melting point for a solid is best represented by the extrapolation to the prefusion baseline of its endotherm (28). The known melting point of 68.82O was subtracted from the average value of the instrument readings for the onset of fusion for stearic acid to produce a correction constant of 378.4'.…”

Section: Experimental'mentioning

confidence: 99%

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Solution thermodynamics of alkyl p‐aminobenzoates

Schwartz

Paruta

1976

Journal of Pharmaceutical Sciences

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Section: Experimental'mentioning

confidence: 99%

Section: Experimental'mentioning

confidence: 99%

Solution thermodynamics of alkyl p‐aminobenzoates

Schwartz

Paruta

1976

Journal of Pharmaceutical Sciences

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“…2. An indirect method, based upon the analysis of a melting scan by the general procedure applicable to nearly pure crystalline substances; this can furnish enantiomeric purity information of fair precision [2][3][4][5].…”

Section: Determination Of Puritymentioning

confidence: 99%

Characterization of chiral building blocks for vitamin D metabolites by DSC

Merker¹,

Schultze²,

Schrötter³

1988

Journal of Thermal Analysis

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The enantiometric purity of a vitamin D3 metabolite was determined more exactly by means of DSC than by ~ H-NMR. The melting curve was analysed by the partial area method based on the Schr6der-van Laar equation. In order to find a suitable method for separation(R)-2,3-dihydroxy-3--methylbutyl p-toluenesulfonate from the racemate, the phase diagram of the enantiomers was evaluated from DSC results. The occurrence of a racemic compound was confirmed by an X-ray diffraction investigation of the racemate and the enantiomers. The conclusions are discussed in comparison with the results of previous investigations.Both the drug activities and the undesired side-effects of enantiomers can differ extremely. The enantiomeric purity of bioactive components is therefore highly important, as was demonstrated by the Contergan disaster, for example.The enantiomeric purity of (R)-2,3-dihydroxy-3-methylbutyl p-toluenesulfonate HO~ H HaC--~ SO2--0"~< OH for the synthesis of (24R)-24, 25-dihydroxy-vitamin D3, and also that of the (S) enantiomer, were determined by 1H-NMR spectroscopy [1]. An enantiomeric purity of 94% or higher was determined. This result was not satisfactory. Therefore, the problem arose of finding a method of determining the purity more exactly. DSC seemed to be an interesting method. John Wiley & Sons, Limited, ChichesterA kad dmiai K i~16, Budapest

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“…The use of an agar-diffusion test with mammalian cells to screen for potential antitumor agents is based either on the loss of the capacity of mammalian cells in agar suspension to reduce an indicator dye to suitable oxidation-reduction potential in the presence of the test compound (1)(2)(3) or the inhibition of cell growth in the agar media in the presence of the toxic agent (4,5). The authors have examined the former method as a screen for compounds of potential interest as antitumor agents and have used cells from three sources:…”

Section: Dophenol-viable Cell Detectionmentioning

confidence: 99%