More and more attention is being paid to extrusion with multi-hole die in the manufacturing industry because of its advantages of high efficiency, high accuracy. However, there is a key factor that need to be taken into cosideration, such as diehole lacation on the multi-hole die. A optimization strategy integrated regression analysis for the multi-hole die design in profile extrusion process based on finite element simulation, GA, and regression theory was proposed, and an optimized model is established to predict the best location of diehole. A few examples show that the strategy is effective, feasible, and the model is accurate, applicable.