Applications of electrochemical sensors and biosensors based on modified screen-printed electrodes: a review

Beitollahi, Hadi; Mohammadi, Sayed Zia; Safaei, Mohadeseh; Tajik, Somayeh

doi:10.1039/c9ay02598g

Cited by 142 publications

(78 citation statements)

References 137 publications

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“…Biomolecule sensing devices, such as glucose-sensing patches, promise a transformative way to continuously assess crucial biomarkers, making their development critical in the future of healthcare development [ 12 , 14 , 15 , 16 ]. Traditional biosensing methods, as discussed in the introduction, are highly limited because of exceptional costs and the inability to record results continuously in real-time, whereas printed biosensors are well suited to long-term, continuous monitoring in an affordable and wearable package [ 12 , 13 ].…”

Section: Applications For Bioelectronicsmentioning

confidence: 99%

“…Likewise, traditional biosensing methods, such as florescent microarrays, lateral flow immunoassays, DNA microarrays, enzyme-linked immunosorbent assays, and polymerase chain reaction-based methods require expensive reagents and laboratory equipment, and are limited by slow signal processing methods; however, fully printed sensors allow for real time, continuous biomarker quantification in a simple, affordable, and mass producible package [ 12 , 13 ]. Printed biomolecule sensors promise a transformative way to continuously assess crucial biomarkers, making their development critical in the future of healthcare development [ 12 , 14 , 15 , 16 ]. These systems were initially fabricated with traditional micro- and nano-electromechanical systems (MEMS/NEMS) approaches, but such techniques are poorly suited for the industrial scales necessary to commercialize hybrid electronics.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

2021

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Hybrid flexible bioelectronic systems refer to integrated soft biosensing platforms with tremendous clinical impact. In this new paradigm, electrical systems can stretch and deform with the skin while previously hidden physiological signals can be continuously recorded. However, hybrid flexible bioelectronics will not receive wide clinical adoption until these systems can be manufactured at industrial scales cost-effectively. Therefore, new manufacturing approaches must be discovered and studied under the same innovative spirit that led to the adoption of novel materials and soft structures. Recent works have taken mature manufacturing approaches from the graphics industry, such as gravure, flexography, screen, and inkjet printing, and applied them to fully printed bioelectronics. These applications require the cohesive study of many disparate parts. For instance, nanomaterials with optimal properties for each specific application must be dispersed in printable inks with rheology suited to each printing method. This review summarizes recent advances in printing technologies, key nanomaterials, and applications of the manufactured hybrid bioelectronics. We also discuss the existing challenges of the available nanomanufacturing methods and the areas that need immediate technological improvements.

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Section: Applications For Bioelectronicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

2021

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“…Aggregated doped or undoped nanomaterials onto various electrode surface increased the reaction ability as well as conductivity of the surface of composite material for the oxidation of target analytes. These excellent sensitivity and high electro‐chemical performances of the composite/material modified electrode are due to the aggregation of materials, which significantly enhanced the oxidation of target selective analyte [33–36] …”

Section: Introductionmentioning

confidence: 99%

Development of a 4‐Nitrophenylhydrazine Sensor Based on MgTi₂O₄⋅TiO₂⋅Zn₂TiO₄ Nanomaterials

et al. 2021

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The synthesized MgTi2O4⋅TiO2⋅Zn2TiO4 nanomaterial was characterized by XRD (X‐Ray diffraction), SEM (Scanning electron microscopy), EDS (Energy dispersive x‐ray spectroscopy), FTIR (Fourier transform infrared spectroscopy) and PL (Photoluminescence) study. Particles size of MgTi2O4⋅TiO2⋅Zn2TiO4 nanomaterial was found to be 37.3 nm. PL and PLE (Photoluminescence excitation) spectra are showed several peaks including one red PL at 723 nm, when excited at 320 nm. Nanomaterial was subject to electrochemical sensor study. Thin layer of synthesized MgTi2O4⋅TiO2⋅Zn2TiO4 nanomaterials was fabricated onto the glassy carbon electrode (GCE) with conducting binder to result the working electrode of 4‐nitrophenylhydrazine (4‐NPHyd) sensor, which was applied successively to selectively detect the 4‐NPHyd in aqueous phase. The 4‐NPHyd chemical sensor exhibited high sensitivity with lower detection limit, long‐term stability in chemical environment and improved electrochemical responses during sensing performance. The linearity of calibration plot is obtained over the large linear dynamic range (LDR) from 0.1 nM to 0.1 mM of 4‐NPHyd. The sensitivity calculated from the slop of calibration plot (ratio of current to concentration of 4‐NPHyd) is 42.7215 μAmM−1cm−2 with detection limit (DL) of 0.02±0.001 nM at signal to noise ratio of 3(S/N). Therefore, the chemical sensor based on MgTi2O4⋅TiO2⋅Zn2TiO4 nanomaterials may be a promising highly sensitive sensor in electrochemical method for the effective detection of hazardous and carcinogenic chemicals in medical as well as biological sectors.

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“…Screen-printed electrodes (SPEs) offer a number of advantages over more traditional electrode formats (e.g., three-electrode cells encompassing individual counter, reference and working electrodes). Advantages include low cost and ease of fabrication, simple cleaning processes, integration of the three-electrode cell onto an on-chip format, and they provide repeatable and reliable measurements with rapid time-to-result [ 24 , 25 ]. SPEs are particularly valuable for both prototyping and integration into rapid POC diagnostics since they can be mass-produced at relatively low cost compared to other types of macroelectrode or microelectrode [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Rapid, Antimicrobial Susceptibility Test for E. coli Based on Low-Cost, Screen-Printed Electrodes

et al. 2020

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Antibiotic resistance has been cited by the World Health Organisation (WHO) as one of the greatest threats to public health. Mitigating the spread of antibiotic resistance requires a multipronged approach with possible interventions including faster diagnostic testing and enhanced antibiotic stewardship. This study employs a low-cost diagnostic sensor test to rapidly pinpoint the correct antibiotic for treatment of infection. The sensor comprises a screen-printed gold electrode, modified with an antibiotic-seeded hydrogel to monitor bacterial growth. Electrochemical growth profiles of the common microorganism, Escherichia coli (E. coli) (ATCC 25922) were measured in the presence and absence of the antibiotic streptomycin. Results show a clear distinction between the E. coli growth profiles depending on whether streptomycin is present, in a timeframe of ≈2.5 h (p < 0.05), significantly quicker than the current gold standard of culture-based antimicrobial susceptibility testing. These results demonstrate a clear pathway to a low cost, phenotypic and reproducible antibiotic susceptibility testing technology for the rapid detection of E. coli within clinically relevant concentration ranges for conditions such as urinary tract infections.

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Applications of electrochemical sensors and biosensors based on modified screen-printed electrodes: a review

Abstract: The focus of this report is electroanalysis performed via screen-printed electrodes.

Cited by 142 publications

References 137 publications

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

Development of a 4‐Nitrophenylhydrazine Sensor Based on MgTi₂O₄⋅TiO₂⋅Zn₂TiO₄ Nanomaterials

Development of a Rapid, Antimicrobial Susceptibility Test for E. coli Based on Low-Cost, Screen-Printed Electrodes

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Applications of electrochemical sensors and biosensors based on modified screen-printed electrodes: a review

Abstract: The focus of this report is electroanalysis performed via screen-printed electrodes.

Cited by 142 publications

References 137 publications

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

Recent Advances in High-Throughput Nanomaterial Manufacturing for Hybrid Flexible Bioelectronics

Development of a 4‐Nitrophenylhydrazine Sensor Based on MgTi2O4⋅TiO2⋅Zn2TiO4 Nanomaterials

Development of a Rapid, Antimicrobial Susceptibility Test for E. coli Based on Low-Cost, Screen-Printed Electrodes

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Development of a 4‐Nitrophenylhydrazine Sensor Based on MgTi₂O₄⋅TiO₂⋅Zn₂TiO₄ Nanomaterials