Applications of electrochemical sensors: Forensic drug analysis

Shaw, Lynsey; Dennany, Lynn

doi:10.1016/j.coelec.2017.05.001

Cited by 105 publications

(45 citation statements)

References 48 publications

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“…Other drugs such as ketamine are currently accepted for medical use and have a moderate potential for abuse and low risk of dependence. As reviewed by Shaw and Dennany [48], electrochemical biosensors are a powerful tool in the forensic field for the analysis of these substances at low concentration in complex matrixes. Campuzano et al also revised the use of electrochemical nucleic-acid-based biosensors for the determination of drugs of abuse and pharmaceuticals [49].…”

Section: Illicit Drugsmentioning

confidence: 99%

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

et al. 2019

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This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis. Highlighted examples that show the advantages of these tools to develop methods capable of detecting very small concentrations of analytes and provide selective determinations through analytical responses, without significant interferences from other components of the samples, are presented and discussed, thus stressing the great versatility and utility of electrochemical biosensors in this growing research field. To illustrate this, the determination of substances with forensic relevance by using electrochemical biosensors reported in the last five years (2015–2019) are reviewed. The different configurations of enzyme or affinity biosensors used to solve analytical problems related to forensic practice, with special attention to applications in complex samples, are considered. Main prospects, challenges to focus, such as the fabrication of devices for rapid analysis of target analytes directly on-site at the crime scene, or their widespread use and successful applications to complex samples of interest in forensic analysis, and future efforts, are also briefly discussed.

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Section: Illicit Drugsmentioning

confidence: 99%

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

et al. 2019

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“…In addition, availability of portable, miniaturization, automation and affordable instruments with higher performance characteristics together with reasonable limits of detection and acceptable selectivity successfully cope with the demands for the determination of illicit substances in the black drug market. Notwithstanding the wide applications of electrochemical sensors for the determination of illicit substances [18][19][20][21][22], little has been reported about the determination of new psychoactive substances [22][23][24]. Moreover, it is of importance to mention that no chemical sensors have been performed yet for the determination of mCPP.…”

Section: N Hn CLmentioning

confidence: 99%

Potentiometric Signal Transduction for Selective Determination of 1-(3-Chlorophenyl)piperazine “Legal Ecstasy” Through Biomimetic Interaction Mechanism

El-Naby

2019

Chemosensors

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1-(3-chlorophenyl)piperazine (mCPP) is a wide spread new psychoactive substance produces stimulant and hallucinogenic effects similar to those sought from ecstasy. Hence, in the recent years, mCPP has been introduced by the organized crime through the darknet as a part of the illicit ecstasy market with a variable complex profile of pharmacologically active substances that pose problematic risk patterns among people who take these seized products. Accordingly, the design of selective sensors for the determination of mCPP is a very important demand. In this respect, a supramolecular architecture; [Na(15-crown-5)][BPh4] from the assembly of 15-crown-5 and sodium tetraphenylboron has been utilized as an ionophore, for the first time in the selective recognition of mCPP in conjunction with potassium tetrakis(p-chlorophenyl)borate and dioctylphthalate through polymeric membrane ion sensors. The ionophore exhibited a strong binding affinity that resulted in a high sensitivity with a slope closed to the ideal Nernstian value; 58.9 ± 0.43 mV/decade, a larger dynamic range from 10−6 to 10−2 M, a lower limit of detection down to 5.0 × 10−7 M and a fast response time of 5 s. Very important also is it was afforded excellent selectivity towards mCPP over psychoactive substances of major concern, providing a potentially useful system for the determination of mCPP in the illicit market. On comparison with the natural β-cyclodextrin as an ionophore, it exhibited more sensitivity and selectivity estimated to be the superior.

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“…There exist numerous analytically oriented studies including SWV and their full citation is vir-tually impossible, thus only a few representative examples will be briefly mentioned. A useful collection of references on the analytical application of SWV can be found in the recent reviews on electrochemical sensors for forensic drug analysis [50], application of bismuth electrodes in contemporary electroanalysis [51], electrochemical biosensors [52], and electrochemical methods for determination of the antioxidant capacity of food [53]. Cao et al presented an advanced state-of-the-art strategy for multi-antibiotics detection using SWV [54].…”

Section: Electrode Mechanisms and Analytical Applicationsmentioning

confidence: 99%

Recent Advances and Prospects of Square-Wave Voltammetry

2018

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This review concerns recent methodological advances of square-wave voltammetry as one of the most sophisticatedmembers of the pulse voltammetric techniques. Besides addressing recent theoretical works and representatives ofadvanced analytical studies, an emphasis is given to a few novel methodological concepts such as kinetic analysis atconstant scan rate, cyclic square-wave voltammetry, multisampling square-wave voltammetry, and electrochemical faradaicspectroscopy. For the purpose of improving analytical performances of the technique two new methods are proposedfor the first time.

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Applications of electrochemical sensors: Forensic drug analysis

Cited by 105 publications

References 48 publications

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

Potentiometric Signal Transduction for Selective Determination of 1-(3-Chlorophenyl)piperazine “Legal Ecstasy” Through Biomimetic Interaction Mechanism

Recent Advances and Prospects of Square-Wave Voltammetry

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