Applications of Fluorescence in Situ Hybridization (FISH) for Detecting Genetic Changes in Hematological Malignancies

Taştemir, Deniz; Demirhan, Özkan; Gürkan, Emel; Tunç, Erdal

doi:10.4236/jct.2011.22014

Cited by 2 publications

(1 citation statement)

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“…Array CGH is a method of high resolution genome wide screening of segmental Copy Number Variations (CNV) used to detect unbalanced chromosomal abnormalities ( 11 ) . FISH is a technique used to identify numerical and structural chromosomal abnormalities and to determine the chromosomal location of specific sequences (12 ) . Single nucleotide polymorphism (SNP) microarray is another versatile diagnostic technique which has many benefits other than diagnosis (13).…”

Section: Introductionmentioning

confidence: 99%

Knowledge on Genetic and Genomic Diagnostics among Sri Lankan Medical Practitioners

Jayawardana

2020

Preprint

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Objectives : Up-to-date knowledge on changing genetic and genomic diagnostic approaches is essential for a contemporary medical practitioner. This study was carried out to describe Sri Lankan Medical Practitioners’ current knowledge and opinion on modern genetic and genomic diagnostics techniques. Results : Data was collected to an electronic database using an online self-administered questionnaire. A total of 123 respondents completed the questionnaire. Majority had either some or adequate knowledge on applications of basic genetic diagnostic methods such as karyotyping and polymerase chain reaction. Similarly most had either some or adequate knowledge on the use of predictive genetic tests in cancer. However the level of knowledge on the applications of modern diagnostic techniques like Fluorescent in-Situ Hybridization and Next Generation Sequencing remained poor. Majority had inadequate knowledge on newer concepts such as direct-to-consumer genetic testing and personalized medicine. Most agreed upon the inadequacy of undergraduate genetic education and the need of a continuous medical education program to fill this knowledge gap. Both undergraduate and continuous medical education approaches should be modified to improve the knowledge on increasingly complicated technological and ethical aspects associated with modern genetic diagnostics.

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Section: Introductionmentioning

confidence: 99%