Applications of functionalized and nanoparticle-modified nanocrystalline cellulose

Lam, Edmond; Male, Keith B.; Chong, Jonathan H.; Leung, Alfred C. W.; Luong, John H. T.

doi:10.1016/j.tibtech.2012.02.001

Cited by 386 publications

(229 citation statements)

References 61 publications

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“…Bioactive, fluorescent nanocrystalline cellulose (NCC) has recently been shown to provide numerous interesting applications [23] which includes quantification and localization of nanoparticles within cells [24] using positively charged fluorescent NCC for bio-imaging, and the attachment of peptide and enzyme fluorophores to NCC for biosensing. For example fluorescent cellulose analogs derivatized with rhodamine B or fluorescein-5-isothiocyanate [25] have been assessed for cellular imaging.…”

Section: Cellulose-based Fluorescent Detectionmentioning

confidence: 99%

Nanocellulose-Based Biosensors: Design, Preparation, and Activity of Peptide-Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity

Edwards¹,

Prevost²,

French³

et al. 2013

ENG

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Nanocrystalline cellulose is an amphiphilic, high surface area material that can be easily functionalized and is biocompatible and eco-friendly. It has been used singularly and in combination with other nanomaterials to optimize biosensor design. The attachment of peptides and proteins to nanocrystalline cellulose and their proven retention of activity provide a route to bioactive conjugates useful in designs for point of care biosensors. Elastase is a biomarker for a number of inflammatory diseases including chronic wounds, and its rapid sensitive detection with a facile approach to sensing is of interest. An increased interest in the use of elastase sensors for point of care diagnosis is resulting in a variety of approaches to elsastase sensors utilizing different detection technologies. Here elastase substrate peptide-celluose conjugates synthesized as colorimetric and fluorescent sensors on cotton cellulose nanocrystals are compared. The structure of the sensor peptide-nanocellulose crystals when modeled with computational crystal structure parameters demonstrates the spatio-stoichiometric features of the nanocrystalline surface that allows ligand to active site protease interacttion. An understanding of the structure/function relations of enzyme and conjugate substrate of the peptides covalently attached to nancellulose has implications for enhancing the biomolecular transducer. The potential applications of both fluorescent and colorimetric detection to markers like elastase using peptide cotton cellulose nanocrystals as a transducer surface to model point of care biosensors for protease detection are discussed.

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Section: Cellulose-based Fluorescent Detectionmentioning

confidence: 99%

Nanocellulose-Based Biosensors: Design, Preparation, and Activity of Peptide-Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity

Edwards¹,

Prevost²,

French³

et al. 2013

ENG

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“…For example, nanocelluloses could be used in functional coatings, barrier coatings, strength additives, films, emulsions, foams, optical devices, adhesives, composites, biomedical engineering materials, cement, packaging, fillers, nonwoven materials, textiles, and separation membranes. [3][4][5][6][7][8][9][10][11] Two types of nanocellulose [12] can be derived from the cellulose in wood: nanofibrillated cellulose (NFC) and nanocrystalline cellulose (NCC). NFC is spaghetti-like in structure, long and flexible, composed of fibers less than 100 nm in width and several micro meter in length, containing both crystalline and amorphous regions.…”

Section: Doi: 101002/gch2201700045mentioning

confidence: 99%

“…The partial depolymerization of cellulosic materials can lead to the fabrication of nanocellulose. [3][4][5][6][7][8][9][10][11] There is significant research activity on future applications of this cellulose-derived nanomaterial by the use of an active radical initiator and a nonselective chlorinebased oxidant is a disadvantage in large-scale production.…”

Section: Nanocellulosesmentioning

confidence: 99%

“…The direct attachment of organic amines such as aminopropyl (AmP) silane 1e is also notable, as the corresponding amino-functionalized NFC could be used as a sustainable support for catalysts (e.g., metals and enzymes) and as a binder of metals. [8,35] Here, the AmP-NFC foam material efficiently bound Pd(II) salts to form AmP-NFC-Pd(II)-complexes. In addition, the subsequent reduction of Pd(II) with NaBH 4 gave the corresponding AmP-NFC-Pd(0) foam containing Pd nanoparticles (Figure 2).…”

Section: Nanocellulosesmentioning

confidence: 99%

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Sustainable Design for the Direct Fabrication and Highly Versatile Functionalization of Nanocelluloses

et al. 2017

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This study describes a novel sustainable concept for the scalable direct fabrication and functionalization of nanocellulose from wood pulp with reduced energy consumption. A central concept is the use of metal‐free small organic molecules as mediators and catalysts for the production and subsequent versatile surface engineering of the cellulosic nanomaterials via organocatalysis and click chemistry. Here, “organoclick” chemistry enables the selective functionalization of nanocelluloses with different organic molecules as well as the binding of palladium ions or nanoparticles. The nanocellulosic material is also shown to function as a sustainable support for heterogeneous catalysis in modern organic synthesis (e.g., Suzuki cross‐coupling transformations in water). The reported strategy not only addresses obstacles and challenges for the future utilization of nanocellulose (e.g., low moisture resistance, the need for green chemistry, and energy‐intensive production) but also enables new applications for nanocellulosic materials in different areas.

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“…As one of the most common organic polymers, cellulose is considered as an almost inexhaustible source of raw material for the increasing demand for making environmentally friendly and biocompatible products. Cellulose nanocrystals (CNC) are rod-like defect free crystalline nanoparticles obtained after the acid hydrolysis of cellulose fibers, and they have special advantages including high surface areas, unique morphology, low density, and low thermal-expansion mechanical strength because of their nano scale dimensions [2][3][4]. These characteristics make cellulose nanocrystals suitable as nanofiller for some polymer materials.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Blend Films Based on Poly(vinyl alcohol) and Cellulose Nanocrystals

Liu

Meng²,

Wang³

et al. 2015

Proceedings of the 2015 International Conference on Education, Management, Information and Medicine

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Abstract. Hardwood dissolving pulp was used as the raw material for the preparation of cellulose nanocrytals (CNC) by sulfuric acid hydrolysis. CNC was added into the solutions of Polyvinyl alcohol (PVA) to prepared PVA/CNC blend films. The miscibility of PVA/CNC films were studied by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The strong hydrogen bonding was formed between the CNC and PVA in the mixing process, and also produced cross-linking between molecular. When the concentration of CNC was 1.0%, tensile strength and breaking tensile strain of blend films reached the max, with the increasing amount of CNC, flocculation of CNC was aggravated, and the compatibility of PVA and CNC was deteriorated, the mechanical properties of blend films were reduced.

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Applications of functionalized and nanoparticle-modified nanocrystalline cellulose

Cited by 386 publications

References 61 publications

Nanocellulose-Based Biosensors: Design, Preparation, and Activity of Peptide-Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity

Nanocellulose-Based Biosensors: Design, Preparation, and Activity of Peptide-Linked Cotton Cellulose Nanocrystals Having Fluorimetric and Colorimetric Elastase Detection Sensitivity

Sustainable Design for the Direct Fabrication and Highly Versatile Functionalization of Nanocelluloses

Preparation and Properties of Blend Films Based on Poly(vinyl alcohol) and Cellulose Nanocrystals

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