Applications of Gold and Silver Nanoparticles in Theranostics

Devi, R Sakthi; Girigoswami, Agnishwar; Siddharth, M; Girigoswami, Koyeli

doi:10.1007/s12010-022-03963-z

Cited by 90 publications

(51 citation statements)

References 182 publications

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“…However, despite concerns for the unavoidable biological safety in vivo, most gold/silver nanoparticles are approved for imaging and diagnosis of cancer in clinical application [ 92 , 93 ]. The biological toxicity of AuNP/Silver NP mainly depends on their physical properties and surface chemical toxicity [ 94 ]. In recent years, green surface modification was applied for their biosafety improvement ( Figure 1 ) [ 48 , 49 , 95 ].…”

Section: The Nanocarriers For Cancer Targeting Therapymentioning

confidence: 99%

Tumor Microenvironment Regulation and Cancer Targeting Therapy Based on Nanoparticles

Han

Chi

Zhu

et al. 2023

JFB

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Although we have made remarkable achievements in cancer awareness and medical technology, there are still tremendous increases in cancer incidence and mortality. However, most anti-tumor strategies, including immunotherapy, show low efficiency in clinical application. More and more evidence suggest that this low efficacy may be closely related to the immunosuppression of the tumor microenvironment (TME). The TME plays a significant role in tumorigenesis, development, and metastasis. Therefore, it is necessary to regulate the TME during antitumor therapy. Several strategies are developing to regulate the TME as inhibiting tumor angiogenesis, reversing tumor associated macrophage (TAM) phenotype, removing T cell immunosuppression, and so on. Among them, nanotechnology shows great potential for delivering regulators into TME, which further enhance the antitumor therapy efficacy. Properly designed nanomaterials can carry regulators and/or therapeutic agents to eligible locations or cells to trigger specific immune response and further kill tumor cells. Specifically, the designed nanoparticles could not only directly reverse the primary TME immunosuppression, but also induce effective systemic immune response, which would prevent niche formation before metastasis and inhibit tumor recurrence. In this review, we summarized the development of nanoparticles (NPs) for anti-cancer therapy, TME regulation, and tumor metastasis inhibition. We also discussed the prospect and potential of nanocarriers for cancer therapy.

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Section: The Nanocarriers For Cancer Targeting Therapymentioning

confidence: 99%

Tumor Microenvironment Regulation and Cancer Targeting Therapy Based on Nanoparticles

Han

Chi

Zhu

et al. 2023

JFB

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“…Due to their easy synthesis, desirable properties, biocompatibility and environmental friendliness, they are suitable for use in many scientific and technological fields [ 34 ]. Several reports using gold/silver nanoparticles and have been published [ 35 , 36 , 37 , 38 ]. A simple and highly selective colorimetric probe for the determination of Ag + ion was described in paper [ 37 ].…”

Section: Analytical Techniques For Silver Determinationmentioning

confidence: 99%

A Review of Analytical Techniques for the Determination and Separation of Silver Ions and Its Nanoparticles

et al. 2023

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Many articles have already been published dealing with silver ions and its nanoparticles, but mostly from the environmental and toxicological point of view. This article is a review focused on the various analytical techniques and detection platforms used in the separation and determination of mentioned above species, especially on the trace concentration level. Commonly used are optical methods because of their high sensitivity and easy automation. The separation methods are mainly used for the separation and preconcentration of silver particles. Their combination with other analytical techniques, mainly inductively coupled plasma mass spectrometry (ICP-MS) leads to very low detection limits of analysis. The electrochemical methods are also powerful and perspective mainly because of the fabrication of new sensors designed for silver determination. All methods may be combined with each other to achieve a synergistic improvement of analytical parameters with an impact on sensitivity, selectivity and reliability. The paper comprises a review of all three types of analytical methods on the determination of trace quantities of silver ions and its nanoparticles.

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“…Останнім часом нанотехнології стали перспективною областю досліджень та мають безліч застосувань у сільському господарстві, особливо використання наночастинок для боротьби з хворобами рослин та підвищення врожайності сільськогосподарських культур [24]. Наночастинки срібла корисні в медицині та медичних пристроях, біотехнології, електроніці чи науці про навколишнє середовище [25][26][27]. НЧ Ag широко застосовуються також у продуктах охорони здоров'я, харчової промисловості та одягу [28,29].…”

Section: вступunclassified

SYNTHESIS OF NOBLE METAL NANOPARTICLES AND THEIR USE IN SENSOR DEVICES, PART 1: SYNTHESIS OF Ag, Au NANOPARTICLES

Skobeeva¹,

Smyntyna²,

Lepikh³

2023

SEMST

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Noble metal nanoparticles are of great importance in the field of biomedicine due to their very diverse applications as antivirals drugs, diagnostic methods, drug carriers and imaging probes. These nanosized materials, in particular gold and silver nanoparticles, are useful as optical probes for detecting a wide range of biological analytes and as promising candidates for the development of highly reliable and ultrasensitive metal nanobiosensors. The success of the practical application nanoparticles depends on the development of safety, simple, efficient, scalable and environmentally friendly synthesis methods. For this has been successfully developed various green protocols using a variety of plant species, algae, fungi, bacteria and other microorganisms. In the first part of this article have been presented information about traditional methods for the synthesis of nanoparticles, with an emphasis on the most common, chemical method, an overview of recent advances in the field of green synthesis of metal nanoparticles involving plants, their likely synthetic mechanism, characterization methods and factors influencing their synthesis. Have been determined the problems of biological synthesis and ways to solve them in the future.

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Applications of Gold and Silver Nanoparticles in Theranostics

Cited by 90 publications

References 182 publications

Tumor Microenvironment Regulation and Cancer Targeting Therapy Based on Nanoparticles

Tumor Microenvironment Regulation and Cancer Targeting Therapy Based on Nanoparticles

A Review of Analytical Techniques for the Determination and Separation of Silver Ions and Its Nanoparticles

SYNTHESIS OF NOBLE METAL NANOPARTICLES AND THEIR USE IN SENSOR DEVICES, PART 1: SYNTHESIS OF Ag, Au NANOPARTICLES

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