Applications of Gold Nanoparticles in Optical Biosensors

Nie, Libo; Liu, Fuhua; Ma, Pengtao; Xiao, Xiangyun

doi:10.1166/jbn.2014.1987

Cited by 101 publications

(51 citation statements)

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“…But since the inelastically scattered light is only a tiny part of light scattered from a sample (<10 −8 ), Raman spectroscopy in general has a weak signal-to-noise ratio, and there is a need for signal enhancement. Using SERS, the Raman signal of small molecules is enhanced by utilizing the collective oscillations of conducting electrons (surface plasmons) that take place in the vicinity of clustered noble-metal nanoparticles1314. SERS has been used in a wide array of medical applications151617.…”

mentioning

confidence: 99%

SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients

Lauridsen

Sommer

Johansen

et al. 2017

Sci Rep

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Pseudomonas aeruginosa is the primary cause of chronic airway infections in cystic fibrosis (CF) patients. Persistent infections are seen from the first P. aeruginosa culture in about 75% of young CF patients, and it is important to discover new ways to detect P. aeruginosa at an earlier stage. The P. aeruginosa biomarker hydrogen cyanide (HCN) contains a triple bond, which is utilized in this study because of the resulting characteristic C≡N peak at 2135 cm−1 in a Raman spectrum. The Raman signal was enhanced by surface-enhanced Raman spectroscopy (SERS) on a Au-coated SERS substrate. After long-term infection, a mutation in the patho-adaptive lasR gene can alter the expression of HCN, which is why it is sometimes not possible to detect HCN in the breath of chronically infected patients. Four P. aeruginosa reference strains and 12 clinical P. aeruginosa strains isolated from CF children were evaluated, and HCN was clearly detected from overnight cultures of all wild type-like isolates and half of the later isolates from the same patients. The clinical impact could be that P. aeruginosa infections could be detected at an earlier stage, because daily breath sampling with an immediate output could be possible with a point-of-care SERS device.

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mentioning

confidence: 99%

SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients

Lauridsen

Sommer

Johansen

et al. 2017

Sci Rep

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“…33 Presently, radionuclide labeling is the only technique that can be used to provide in situ quantitative information-, but radio emitters may be too unstable to conjugate with nano-materials. 33 With the help of recently developed in vivo imaging probes like magnetic nanoparticles, 34, 35 quantum dots, 36, 37 gold nanoparticles, 38, 39 and carbon nanotubes, 40, 41 more imaging modalities may become available to track the distribution of nano-therapeutics in the body.…”

Section: Combination Chemotherapeuticsmentioning

confidence: 99%

Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging

Glasgow¹,

Mb²

2015

j biomed nanotechnol

110

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Nanotechnology and combination therapy are two major fields that show great promise in the treatment of cancer. The delivery of drugs via nanoparticles helps to improve drug’s therapeutic effectiveness while reducing adverse side effects associated with high dosage by improving their pharmacokinetics. Taking advantage of molecular markers over-expressing on tumor tissues compared to normal cells, an “active” molecular marker targeted approach would be beneficial for cancer therapy. These actively targeted nanoparticles would increase drug concentration at the tumor site, improving efficacy while further reducing chemo-resistance. The multidisciplinary approach may help to improve the overall efficacy in cancer therapy. This review article summarizes recent developments of targeted multifunctional nanoparticles in the delivery of various drugs for a combinational chemotherapy approach to cancer treatment and imaging.

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“…Their high biocompatibility and versatile surface properties allow gold nanoparticles to be a safe platform for many biomedical technologies. Gold nanoparticles have been employed as optical biosensors [11], drug delivery vehicles [12], and imaging contrast agents [13] and laser-based treatments [14]. Their simple formulation and reactive surface allow for a variety of molecules including drugs, targeting peptides or proteins, contrast agents, or other moieties to be attached.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Mahan

Doiron

2018

Journal of Nanomaterials

116

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Computed tomography (CT) is among the most popular medical imaging modalities due to its high resolution images, fast scan time, low cost, and compatibility with all patients. CT scans of soft tissues require the localization of imaging contrast agents (CA) to create contrast, revealing anatomic information. Gold nanoparticles (AuNP) have attracted interest recently for their use as CT CA due to their high X-ray attenuation, simple surface chemistry, and biocompatibility. Targeting molecules may be attached to the particles to allow for the targeting of specific cell types and disease states. AuNP can also be readily designed to incorporate other imaging contrast agents such as rare earth metals and dyes. This review summarizes the current state-of-the-art knowledge in the field of AuNP used as X-ray and multimodal contrast agents. Primary research is analyzed through the lens of structure-propertyfunction to best explain the design of a particle for a given application. Design specification of particles includes size, shape, surface functionalization, composition, circulation time, and component synergy. Key considerations include delivery of a CA payload to the site of interest, nontoxicity of particle components, and contrast enhancement compared to the surrounding tissue. Examples from literature are included to illustrate the strategies used to address design considerations.

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Applications of Gold Nanoparticles in Optical Biosensors

Cited by 101 publications

References 0 publications

SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients

SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients

Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

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