Dew point temperature (DPT) is known to fluctuate in space and time regardless of the climatic zone considered. The accurate estimation of the DPT is highly significant for various applications of hydro and agro–climatological researches. The current research investigated the hybridization of a multilayer perceptron (MLP) neural network with nature-inspired optimization algorithms (i.e., gravitational search (GSA) and firefly (FFA)) to model the DPT of two climatically contrasted (humid and semi-arid) regions in India. Daily time scale measured weather information, such as wet bulb temperature (WBT), vapor pressure (VP), relative humidity (RH), and dew point temperature, was used to build the proposed predictive models. The efficiencies of the proposed hybrid MLP networks (MLP–FFA and MLP–GSA) were authenticated against standard MLP tuned by a Levenberg–Marquardt back-propagation algorithm, extreme learning machine (ELM), and support vector machine (SVM) models. Statistical evaluation metrics such as Nash Sutcliffe efficiency (NSE), root mean square error (RMSE), and mean absolute error (MAE) were used to validate the model efficiency. The proposed hybrid MLP models exhibited excellent estimation accuracy. The hybridization of MLP with nature-inspired optimization algorithms boosted the estimation accuracy that is clearly owing to the tuning robustness. In general, the applied methodology showed very convincing results for both inspected climate zones.