Applications of halloysite in tissue engineering

Functional Nanohybrids and Nanocomposites Development for the Removal of Environmental Pollutants and Bioremediation

“…Halloysite is a natural tubular clay, and one of the most studied, due to its biocompatibility (with low in vivo and in vitro toxicity) and mechanical, physical and chemical (simple inner/outer surfaces functionalization) properties. Due also to its tubular form, it can be loaded with different species to be used for the release of active molecules such as antioxidants [ 172 ], flame-retardants, corrosion inhibitors [ 173 ], biocides and drugs [ 174 ]. In this regard, there are many examples of the use of halloysite loaded or functionalized with different nanomaterials, such as metal or magnetic NPs, for environmental remediation approaches, that are able either to perform pollutant degradation catalytic reactions or to be used as recoverable absorbent systems.…”

XPS, structural and antimicrobial studies of novel functionalized halloysite nanotubes

“…Because of unique physicochemical properties such as large surface area, tubular nanostructure, mechanical strength, availability of functional groups and high biocompatibility HNTs is used in various applications such as a filler in polymeric materials, a carrier for drug delivery in medical and cosmetic formulations, tissue engineering and as absorbent for water treatment [19][20][21][22] . HNTs-based organic-inorganic composites properties and their applications in filters, microbe-resistant biocidal textile, medical formulations, drug delivery, paints and photocatalysis were previously studied and reviewed [23][24][25][26] .…”

PEGylated green halloysite/spinel ferrite nanocomposites for pH sensitive delivery of dexamethasone: A potential pulmonary drug delivery treatment option for COVID-19

“…The external adsorption site (specific surface area) of Hal can be modified by treatment with HCl for effective drug incorporation and influence the release rate of antioxidant such as curcumin ( de Abreu Pereira et al, 2021 ). Halloysite with high tubular surface area, biocompatibility, functionable aluminol and siloxane moieties has been used as a controlled drug release carriers for cancer ( Mo et al, 2021 ), tissue engineering ( Gkouma et al, 2021 ), diabetes mellitus ( Massaro et al, 2018 ), dental ( Karczewski et al, 2021 ), herbicide ( Tan et al, 2015 ), etc. Gold nanoclusters supported on silane modified Hal has been described as an effective nanocomposite inducing non-toxic effect at desired concentration range (25–50 μg/ml) suitable for tumor imaging and cancer therapy ( Gorbachevskii et al, 2021 ).…”