Applications of human amniotic fluid stem cells in wound healing

Abstract

Complete wound regeneration preserves skin structure and physiological functions, including sensation and perception of stimuli, whereas incomplete wound regeneration results in fibrosis and scarring. Amniotic fluid stem cells (AFSCs) would be a kind of cell population with self-renewing and non-immunogenic ability that have a considerable role in wound generation. They are easy to harvest, culture, and store; moreover, they are non-tumorigenic and not subject to ethical restrictions. They can differentiate into different kinds of cells that replenish the skin, subcutaneous tissues, and accessory organs. Additionally, AFSCs independently produce paracrine effectors and secrete them in exosomes, thereby modulating local immune cell activity. They demonstrate anti-inflammatory and immunomodulatory properties, regulate the physicochemical microenvironment of the wound, and promote full wound regeneration. Thus, AFSCs are potential resources in stem cell therapy, especially in scar-free wound healing. This review describes the biological characteristics and clinical applications of AFSCs in treating wounds and provide new ideas for the treatment of wound healing.

The properties of absorbable scaffold harvested with human amniotic fluid stem cells on rat model: an innovation for pelvic reconstruction surgery

“…Although hAFSC accelerate wound healing, mesh degradation over time weakens the tissue-mesh complex. Achieving balance between mesh degradation and stem cell growth is crucial, as premature absorption compromises tissue support 19 , healing takes time. However, over time, despite tissue healing progresses, the absorbable mesh.…”

Amniotic Membrane in the Treatment of Hard-to-Heal Wounds

“…Amniotic membrane and amnion itself are valuable products that should be revisited for their regenerative and antibacterial properties. More recently, a review on the use of amniotic fluid containing stem cells concluded that the use of amniotic fluid requires further research as to how the cell in the fluid will differentiate in the microenvironment of a wound as well as possible therapeutic applications [46].…”

The Properties of Absorbable Scaffold Harvested with Human Amniotic Fluid Stem Cells on Rat Model: Innovation for Pelvic Reconstruction Surgery

“…Despite the unique ability of hAFSC to accelerate skin wound healing by promoting reepithelization of the dermis 22 , tissue healing takes time. However, over time, despite tissue healing progresses, the absorbable mesh degraded, leading to the weakening of the tissue-mesh complex.…”