Applications of Iron Oxide Nanoparticles against Breast Cancer

Hosseinkazemi, Hessam; Samani, Saeed; O’Neill, Andrew; Soezi, Mahdieh; Moghoofei, Mohsen; Azhdari, Mohammad H.; Aavani, Farzaneh; Nazbar, Abolfazl; Keshel, Saeed Heidari; Doroudian, Mohammad

doi:10.1155/2022/6493458

Cited by 26 publications

(10 citation statements)

References 123 publications

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“…Vaccination is the most successful way to prevent and control disease, and it has saved countless lives in both infectious disease and cancer treatment [5,22,23]. At present, nucleic acid vaccines are divided into two categories: plasmid DNA vaccines and mRNA vaccines, both of which have demonstrated potential [22].…”

Section: Mrna Vaccination and Mechanism Of Action Of Mrnamentioning

confidence: 99%

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

et al. 2023

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In recent years, there has been an increase in deaths due to infectious diseases, most notably in the context of viral respiratory pathogens. Consequently, the focus has shifted in the search for new therapies, with attention being drawn to the use of nanoparticles in mRNA vaccines for targeted delivery to improve the efficacy of these vaccines. Notably, mRNA vaccine technologies denote as a new era in vaccination due to their rapid, potentially inexpensive, and scalable development. Although they do not pose a risk of integration into the genome and are not produced from infectious elements, they do pose challenges, including exposing naked mRNAs to extracellular endonucleases. Therefore, with the development of nanotechnology, we can further improve their efficacy. Nanoparticles, with their nanometer dimensions, move more freely in the body and, due to their small size, have unique physical and chemical properties. The best candidates for vaccine mRNA transfer are lipid nanoparticles (LNPs), which are stable and biocompatible and contain four components: cationic lipids, ionizable lipids, polyethylene glycols (PEGs), and cholesterol, which are used to facilitate cytoplasmic mRNA delivery. In this article, the components and delivery system of mRNA-LNP vaccines against viral lung infections such as influenza, coronavirus, and respiratory syncytial virus are reviewed. Moreover, we provide a succinct overview of current challenges and potential future directions in the field.

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Section: Mrna Vaccination and Mechanism Of Action Of Mrnamentioning

confidence: 99%

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

et al. 2023

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“…Such metal anticancer complexes have broad prospects in the field of anticancer research. Hessam Hosseinkazemi et al [ 182 ] reported on the potential use of iron oxide nanoparticles as therapeutic drugs and acknowledged their superiority over traditional therapeutic drugs. Although only used for the treatment of iron-deficiency anemia and cancer, multiple experiments are currently being conducted to promote its clinical application.…”

Section: Metal Anticancer Drugsmentioning

confidence: 99%

Research Progress of Metal Anticancer Drugs

Bai,

Aodeng,

et al. 2023

Pharmaceutics

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Cancer treatments, including traditional chemotherapy, have failed to cure human malignancies. The main reasons for the failure of these treatments are the inevitable drug resistance and serious side effects. In clinical treatment, only 5 percent of the 50 percent of cancer patients who are able to receive conventional chemotherapy survive. Because of these factors, being able to develop a drug and treatment that can target only cancer cells without affecting normal cells remains a big challenge. Since the special properties of cisplatin in the treatment of malignant tumors were accidentally discovered in the last century, metal anticancer drugs have become a research hotspot. Metal anticancer drugs have unique pharmaceutical properties, such as ruthenium metal drugs with their high selectivity, low toxicity, easy absorption by tumor tissue, excretion, and so on. In recent years, efficient and low-toxicity metal antitumor complexes have been synthesized. In this paper, the scientific literature on platinum (Pt), ruthenium (Ru), iridium (Ir), gold (Au), and other anticancer complexes was reviewed by referring to a large amount of relevant literature at home and abroad.

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“…Nanoscale devices and materials can deliver therapeutic drugs specifically to cancer cells, thereby reducing exposure to healthy tissues. [6,7] Nanoparticles (NPs) show particular promise in the treatment of lung cancer, where they can be utilized as drug delivery systems. Incorporating therapeutics that specifically target cancer cells into NPs has shown to be more effective for treatment with fewer side effects.…”

Section: Doi: 101002/adtp202300275mentioning

confidence: 99%

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar,

Fakhr,

Abbasgholinejad

et al. 2023

Advanced Therapeutics

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Lung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy for the treatment of lung cancer, owing to their ability to selectively deliver therapeutic agents to cancer cells while minimizing off‐target effects. Smart NPs can respond to specific stimuli such as changes in pH, temperature, or enzymes, allowing them to release their cargo only when triggered. Among the various types of smart NPs, lipid‐based NPs, including liposomes, solid lipid nanoparticles, cubosomes, and extracellular vesicles, have garnered the highest interest due to their biocompatibility, low toxicity, and versatility in encapsulating a wide variety of drugs and genetic material. This review discusses the current status of smart lipid‐based NPs in lung cancer treatment, including recent advances in targeting strategies, stimuli‐responsive NPs, and combination therapies. The challenges and opportunities associated with translating smart lipid‐based NPs for lung cancer treatment into clinical applications are also discussed. This review highlights the potential of smart lipid‐based NPs to revolutionize lung cancer treatment and improve patient outcomes.

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Applications of Iron Oxide Nanoparticles against Breast Cancer

Cited by 26 publications

References 123 publications

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

Research Progress of Metal Anticancer Drugs

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

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