Applications of Magnetic Nanoparticles in Biomedicine

Bárcena, Carlos; Amandeep, K.; Gao, Jinming

doi:10.1007/978-0-387-85600-1_20

Cited by 376 publications

(31 citation statements)

References 197 publications

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“…16–20 Despite considerable effort however, targeted MION constructs have yet to gain wide clinical acceptance mainly due to interactions with host immune cells, such as macrophages, limiting selective delivery to tissues of interest. 21,22 As a result, it remains an open question whether such molecular targeting indeed leads to improved tumor retention of nanoparticles for cancer imaging and therapy, which has been the subject of several recent reviews.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a PSMA-targeted BNF nanoparticle construct

et al. 2015

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Early detection enables improved prognosis for prostate cancer (PCa). A promising target for imaging and therapy of PCa is the prostate-specific membrane antigen (PSMA), which exhibits both expression within the epithelium of PCa cells, and becomes internalized upon ligand binding. Here we report the synthesis of a PSMA-targeted bionized nanoferrite (BNF) nanoparticle and its biological evaluation in an experimental model of PCa. The BNF nanoparticle formulation exhibits properties conducive to targeted imaging such as stealth, prolonged circulation time and enhanced clearance from non-target sites. Optical imaging of the targeted BNF in vivo indicates preferential accumulation in PSMA+ tumors 4 h post-injection, suggesting target specificity. On the other hand, non-targeted nanoparticles exhibit lower uptake with similar accumulation in both PSMA+ and PSM− tumors indicating tumor access without preferential accumulation. Imaging with single photon emission computed tomography (SPECT) and biodistribution studies of a modified construct indicate highest tumor accumulation at 48 h post-injection [4.3 ± 0.4 percentage injected dose per gram of tissue (%ID g−1)], with tumor/blood and tumor/muscle ratios of 7.5 ± 2.4 and 11.6 ± 1.2 %ID g−1, respectively. Ex vivo fluorescence microscopy, Prussian blue staining, immunohistochemistry and biodistribution studies confirm enhanced nanoparticle uptake in PSMA+ tumors compared to those not expressing PSMA. The BNF nano-formulation described is promising for PSMA-targeted imaging applications in vivo.

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Section: Introductionmentioning

confidence: 99%

Evaluation of a PSMA-targeted BNF nanoparticle construct

et al. 2015

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“…Magnetic nanoparticles are a promising tool for biological and therapeutic applications such as tumor ablation, 1 drug delivery, 2 and magnetic resonance diagnostics. 3 Their low dimensions allow simple insertion into cells 4 and controlled interaction with cellular proteins, 5,6 whereas their magnetic properties enable noninvasive and highly localized mechanical manipulation using external magnetic fields without compromising the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Local mechanical response of cells to the controlled rotation of magnetic nanorods

et al. 2014

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The mechanical response of the cytoplasm was investigated by the intracellular implantation of magnetic nanorods and exposure to low-frequency rotatory magnetic fields. Nanorods (Pt-Ni, ~200 nm diameter) fabricated by electrodeposition in templates of porous alumina with lengths of approximately 2 and 5 μm were inserted into NIH/ 3T3 fibroblasts and manipulated with a rotational magnetic field. Nanorod rotation was observed only for torques greater than 3.0 × 10−16 Nm, suggesting a Bingham-type behavior of the cytoplasm. Higher torques produced considerable deformation of the intracellular material. The cell nucleus and cell membrane were significantly deformed by nanorods actuated by 4.5 × 10−15 Nm torques. Our results demonstrate that nanorods under magnetic fields are an effective tool to mechanically probe the intracellular environment. We envision that our findings may contribute to the noninvasive and direct mechanical characterization of the cytoplasm.

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“…Its small size makes enable to get closer to the desired targets. Although, NMPs coated with some biological interacting molecules that enable it to penetrate or tag the biological object [65]. MNPs obey the coulombs law that means it can be deployed by any outward magnetic gradient.…”

Section: Biomedical Perspectives Of Magnetic Nanomaterialsmentioning

confidence: 99%

Bio-Catalysis and Biomedical Perspectives of Magnetic Nanoparticles as Versatile Carriers

et al. 2019

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In recent years, magnetic nanoparticles (MNPs) have gained increasing attention as versatile carriers because of their unique magnetic properties, biocatalytic functionalities, and capabilities to work at the cellular and molecular level of biological interactions. Moreover, owing to their exceptional functional properties, such as large surface area, large surface-to-volume ratio, and mobility and high mass transference, MNPs have been employed in several applications in different sectors such as supporting matrices for enzymes immobilization and controlled release of drugs in biomedicine. Unlike non-magnetic carriers, MNPs can be easily separated and recovered using an external magnetic field. In addition to their biocompatible microenvironment, the application of MNPs represents a remarkable green chemistry approach. Herein, we focused on state-of-the-art two majorly studied perspectives of MNPs as versatile carriers for (1) matrices for enzymes immobilization, and (2) matrices for controlled drug delivery. Specifically, from the applied perspectives of magnetic nanoparticles, a series of different applications with suitable examples are discussed in detail. The second half is focused on different metal-based magnetic nanoparticles and their exploitation for biomedical purposes.

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Applications of Magnetic Nanoparticles in Biomedicine

Cited by 376 publications

References 197 publications

Evaluation of a PSMA-targeted BNF nanoparticle construct

Evaluation of a PSMA-targeted BNF nanoparticle construct

Local mechanical response of cells to the controlled rotation of magnetic nanorods

Bio-Catalysis and Biomedical Perspectives of Magnetic Nanoparticles as Versatile Carriers

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