Applications of marine collagens in bone tissue engineering

Lin, Ziying; Yu, Tao; Ying, Huang; Xu, Tao; Niu, Wei

doi:10.1088/1748-605x/abf0b6

Cited by 24 publications

(13 citation statements)

References 71 publications

(90 reference statements)

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“…A wide variety of marine biomaterials have been explored to produce tissue engineering scaffolds able to regenerate the bone and cartilage [176]. It is worth emphasizing that most studies only performed a short-term evaluation after material implantation [177]. Hence, the long-term biological performance of the marine biomaterial scaffolds needs to be further determined to verify that these combinations are safe and effective materials.…”

Section: Bone and Cartilage Tissue Engineeringmentioning

confidence: 99%

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Zhang

Liang

et al. 2022

Marine Drugs

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Oceans have vast potential to develop high-value bioactive substances and biomaterials. In the past decades, many biomaterials have come from marine organisms, but due to the wide variety of organisms living in the oceans, the great diversity of marine-derived materials remains explored. The marine biomaterials that have been found and studied have excellent biological activity, unique chemical structure, good biocompatibility, low toxicity, and suitable degradation, and can be used as attractive tissue material engineering and regenerative medicine applications. In this review, we give an overview of the extraction and processing methods and chemical and biological characteristics of common marine polysaccharides and proteins. This review also briefly explains their important applications in anticancer, antiviral, drug delivery, tissue engineering, and other fields.

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Section: Bone and Cartilage Tissue Engineeringmentioning

confidence: 99%

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Zhang

Liang

et al. 2022

Marine Drugs

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“…Then, the collagen can be extracted using acid or enzyme, such as pepsin. [30,155] Scaffolds and composites made of collagen derived from marine resources have been demonstrated to have the potential to stimulate tissue regeneration in vivo, such as bone, [156][157][158] skin, [159] and blood and lymphatic vessels (Figure 5a). [160]…”

Section: Collagen From Byproducts Of Fishing Industriesmentioning

confidence: 99%

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Putra

Zhou

Zadpoor

2023

Adv Healthcare Materials

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The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for sustainable development. Although tissue engineering has rapidly developed, the challenges associated with fulfilling the increasing demand for bone substitutes and implants remain unresolved, particularly as the global population ages. This review provides an overview of waste materials, such as eggshells, seashells, fish residues, and agricultural biomass, that can be transformed into biomaterials for bone tissue engineering. While the development of recycled metals is in its early stages, we highlight the use of probiotics and renewable polymers to improve the biofunctionalities of bone implants. Despite the advances of additive manufacturing (AM), studies on AM waste‐derived bone‐substitutes are limited. It is foreseeable that AM technologies can provide a more sustainable alternative to manufacturing biomaterials and implants. The preliminary results of eggshell and seashell‐derived calcium phosphate and rice husk ash‐derived silica will likely pave the way for more advanced applications of AM waste‐derived biomaterials for sustainably addressing several unmet clinical applications.This article is protected by copyright. All rights reserved

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“…In the past decades due to the collagen structure and function investigation, various collagen-based scaffolds have been proposed for BTE applications [ 73 , 74 , 75 ]. Collagen, as a connective tissue fibrillar protein, demonstrates biomimetic properties, high elasticity, and provides appropriate conditions for cells adhesion and interaction [ 76 ].…”

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical translation of BTE requires overcoming a number of significant challenges. Currently, insufficient vascularization is the critical limitation for viability of the bone tissue-engineered construct. Furthermore, efficacy and safety of the scaffolds cell-seeding and exogenous growth factors administration are still controversial. The in vivo bioreactor principle (IVB) is an exceptionally promising concept for the in vivo bone tissue regeneration in a predictable patient-specific manner. This concept is based on the self-regenerative capacity of the human body, and combines flap prefabrication and axial vascularization strategies. Multiple experimental studies on in vivo BTE strategies presented in this review demonstrate the efficacy of this approach. Routine clinical application of the in vivo bioreactor principle is the future direction of BTE; however, it requires further investigation for to overcome some significant limitations.

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Applications of marine collagens in bone tissue engineering

Cited by 24 publications

References 71 publications

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

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