Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Abstract

Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.

PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding

“…For example, Jazz Pharmaceuticals proposed the drug Defitelio ®® (defibrotide sodium), which is the oligonucleotide obtained by depolymerization of porcine intestinal mucosal DNA for the treatment of hepatic veno-occlusive disease [ 5 ]. In addition, polynucleotides obtained from marine fish exert a wide therapeutic use [ 6 , 7 , 8 ].…”

The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase

“…PDRN has been used for wound healing and has shown high safety [ 70 ]. Since the topical use of vitamin C and nicotinamide has also shown excellent safety [ 71 , 72 ], we thought that their combination (NVP-mix) could be used safely as a therapeutic for hyperpigmentation.…”

Results of Shoulder Adhesive Capsulitis Treatment With the Use of Platelet Rich Plasma and Nucleotide Drugs: A Comparative Study

“…Многие клинические исследования показали, что лекарственные препараты на основе полинуклеотидов эффективно применяются при многочисленных заболеваниях, связанных с воспалением, включая бурсит, фасциит, мукозит и тендинопатию [14,15,24].…”

“…Структура PN представляет собой низкомолекулярную фракцию дезоксирибонуклеиновой кислоты, где мономерные звенья представлены пуриновыми и пиримидиновыми основаниями [13]. Кроме снижения боли при заболеваниях и повреждениях опорно-двигательного аппарата, PN способствуют регенерации поврежденных сухожилий и связок [14,15,16]. Однако отсутствует единое мнение о том, какая методика PRP-терапии оптимальна при лечении данной патологии, мало сообщений об объективных результатах применения PN при адгезивном капсулите [17,18,19].…”