Applications of Mesenchymal Stem Cells in Sinus Lift Augmentation as a Dental Implant Technology

Abstract

The potential application of stem cell biology in human dentistry is a new and emerging field of research. The objective of the current review was to study the efficiency of mesenchymal stem cells (MSCs) in sinus lift augmentation (SLA). A literature review was performed in PubMed Central using MeSH keywords such as sinus lift, MSCs, dental implants, and augmentation. The searches involved full-text papers written in English, published in the past 10 years (2007–2017). The review included in vitro and in vivo studies on the use of MSCs in SLA. Electronic searching provided 45 titles, and among them, 8 papers were chosen as suitable based on the inclusion requirements of this review. The reviewed studies have revealed the potential of MSCs in SLA. According to these papers, stem cell therapy combined with different biomaterials may considerably improve bone regeneration in previous steps of dental implantation and may veritably lead to efficient clinical usages in the recent future. However, the identification of an ideal source of stem cells as well as long-term studies is vital to assess the success rate of this technology. Further clinical trials are also needed to approve the potential of MSCs in SLA.

Evaluation of the Osteogenic Potential of Different Scaffolds Embedded with Human Stem Cells Originated from Schneiderian Membrane: An In Vitro Study

“…For instance, a previous study comparing early bone formations in patients, with a bilateral highly atrophic posterior maxilla, being grafted with xenogenic sinus graft material (bovine bone material, BBM) alone or BBM admixed with a concentrate of MSCs revealed that MSCs have no positive impact on the new bone formation [58, 59]. On the other hand, there is a growing literature showing that stem cells paired with osteoconductive scaffolding materials can be successfully applied for maxillary sinus lifting as well as bone regeneration [60–66]. Although our obtained results suggest that scaffold-embedded hMSSM-derived cells could support bone regeneration following sinus lift, a major limitation of this study would be that the observed, in vitro , osteoinductive potential of the tested scaffold-embedded hMSSM-derived cells does not necessarily translate into in vivo applicability, thereby limiting their clinical application.…”

Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors: A first-in-human case report and literature review

“…It appears feasible to further improve GBR-MSA by the application of stem cells (for recent reviews on the use of stem cells in regenerative dentistry[35-37]). Among the different types of mesenchymal stem cells, cells derived from adipose tissue (either freshly isolated or culture-expanded) have emerged as a promising tool for GBR[4,38,39].…”

Effects of carbon and nitrogen plasma immersion ion implantation on bioactivity of zirconia

“…It has been widely used in the surface modication of polymers and metals. 18,19,28,29 In this study, we implanted carbon on the surface of zirconia materials by plasma immersion technology to construct an in situ carbonized layer. We then injected nitrogen to form a chemical structure with carbon forming a non-polar covalent bond on the surface of the materials which slightly increased the surface potential.…”

“…[15][16][17] BMSCs therapy combined with different biomaterials may improve bone regeneration in dental implantation. 18,19 Promoting osseointegration of BMSCs on the surface of zirconia ceramics was the focus of this study.…”