Applications of Micro-CT in Cardiovascular Engineering and Bio-inspired Design

Cakmak, Bilgesu; Ermek, Erhan; Jamil, Muhammad; Horasan, Asım; Pekkan, Kerem

doi:10.1007/978-3-030-16641-0_11

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Two 13 French (Fr) DLC devices (both Avalon and Origen) were selected for this study as recommended by our collaborating neonatal intensivists and newborn intensive care unit (NICU) clinicians. Both devices were scanned using micro-CT with an extremely fine resolution (~150 μm) and image data was segmented in slicer software to obtain the 3D reconstruction ( Çakmak et al, 2020 ). To resolve the exact geometry of the infusion and drainage holes, DLCs were scanned under optical coherence tomography (OCT) reaching less than 2 μm resolution.…”

Section: Methodsmentioning

confidence: 99%

Hemodynamic performance limits of the neonatal Double-Lumen cannula

Rasooli

Jamil

Rezaeimoghaddam

et al. 2021

Journal of Biomechanics

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Section: Methodsmentioning

confidence: 99%

Hemodynamic performance limits of the neonatal Double-Lumen cannula

Rasooli

Jamil

Rezaeimoghaddam

et al. 2021

Journal of Biomechanics

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“…The three-dimensional (3D) reconstruction of clinically approved DLC (13Fr Origen Biomedical, Austin, Texas, USA) was obtained from micro-CT (computed tomography) and OCT (optical coherence tomography) image data using Slicer software (www.slicer.org). 13 A normal patient-specific atrium model at diastole was reconstructed from the magnetic resonance imaging (MRI) scan of an anonymized neonatal patient (weight = 3 kg, height = 50 cm, body surface area = 0.2 m 2 ) after Institutional Review Board (IRB) approval (Koc University 2015.156.IRB2.056). The Origen DLC was selected based on its economic viability and clinical availability with no commercial motivation or brand bias.…”

Section: Methodsmentioning

confidence: 99%

Hemodynamics of neonatal double lumen cannula malposition

et al. 2019

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Objective: Malposition of dual lumen cannula is a frequent and challenging complication in neonates and plays a significant role in shaping the in vitro device hemodynamics. This study aims to analyze the effect of the dual lumen cannula malposition on right-atrial hemodynamics in neonatal patients using an experimentally validated computational fluid dynamics model. Methods: A computer model was developed for clinically approved dual lumen cannula (13Fr Origen Biomedical, Austin, Texas, USA) oriented inside the atrium of a 3-kg neonate with normal venous return. Atrial hemodynamics and dual lumen cannula malposition were systematically simulated for two rotations (antero-atrial and atrio-septal) and four translations (two intravascular movements along inferior vena cava and two dislodged configurations in the atrium). A multi-domain compartmentalized mesh was prepared to allow the site-specific evaluation of important hemodynamic parameters. Transport of each blood stream, blood damage levels, and recirculation times are quantified and compared to dual lumen cannula in proper position. Results: High recirculation levels (39 ± 4%) in malpositioned cases resulted in poor oxygen saturation where maximum recirculation of up to 42% was observed. Apparently, Origen dual lumen cannula showed poor inferior vena cava blood–capturing efficiency (48 ± 8%) but high superior vena cava blood–capturing efficiency (86 ± 10%). Dual lumen cannula malposition resulted in corresponding changes in residence time (1.7 ± 0.5 seconds through the tricuspid). No significant differences in blood damage were observed among the simulated cases compared to normal orientation. Compared to the correct dual lumen cannula position, both rotational and translational displacements of the dual lumen cannula resulted in significant hemodynamic differences. Conclusion: Rotational or translational movement of dual lumen cannula is the determining factor for atrial hemodynamics, venous capturing efficiency, blood residence time, and oxygenated blood delivery. Results obtained through computational fluid dynamics methodology can provide valuable foresight in assessing the performance of the dual lumen cannula in patient-specific configurations.

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“…Butcher and collaborators were the rst to adapt micro-CT imaging towards avian models in order to generate quantitative embryonic cardiovascular volumes at different embryonic sta (9). Since this groundbreaking study, micro-CT has been used extensively to study cardiovascular morphology in developing chick embryos (4,8,(35)(36)(37). Speci cally, the technique has proved useful for the extraction of accurate volumetric measurements for the determination of embryonic and fetal myocardium properties, particularly following surgical interferences mimicking CHDs (38).…”

Section: Introductionmentioning

confidence: 99%

An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages

Naïja

Mutlu

Khan

et al. 2023

Preprint

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Compared to classical techniques of morphological analysis, micro-CT (µ-CT) has become an effective approach allowing rapid screening of morphological changes. In the present work, we aimed to provide an optimized µ-CT dense agent perfusion protocol and µ-CT guidelines for different stages of chick embryo cardiogenesis. Our study was conducted over a period of 10 embryonic days (Hamburger-Hamilton HH36) in chick embryo hearts. During the perfusion of the µ-CT dense agent at different developmental stages (HH19, HH24, HH27, HH29, HH31, HH34, HH35, and HH36), we demonstrated that durations and volumes of the injected contrast agent gradually increased with the heart developmental stages contrary to the flow rate that was unchanged during the whole experiment. Analysis of the CT imaging confirmed the efficiency of the optimized parameters of the heart perfusion.

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Applications of Micro-CT in Cardiovascular Engineering and Bio-inspired Design

Cited by 4 publications

References 19 publications

Hemodynamic performance limits of the neonatal Double-Lumen cannula

Hemodynamic performance limits of the neonatal Double-Lumen cannula

Hemodynamics of neonatal double lumen cannula malposition

An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages

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