Applications of Micro/Nano Automation Technology in Detecting Cancer Cells for Personalized Medicine

Abstract

Abstract-The coming era of personalized cancer treatment is presenting automation with unprecedented opportunities. Currently, the drug susceptibility test of clinical cancer patients is mainly dependent on manual labor with a low level of automation. Automating the process of primary cancer cell detection will potentially have tremendous economic benefits and social significance. Automated cancer cell detection means developing robotic and automation equipments to handle single cells and molecules at the micro/nanometer-scale. The achievements of information science, engineering technology, life sciences, and nanotechnology in the past decades have led to the birth of robots that can perform effective manipulations on single living cells at the micro/nanometerscale in aqueous conditions, opening the door to automated cancer cell detection. However, there is still a huge gap between current single-cell micro/nano automation technology and clinical requirements for personalized medicine. In this paper, we will review the progress of single-cell micro/nano automation technology in recent years and discuss the facing challenges and future directions in three aspects, including automated cell isolation and delivery, automatically acquiring the physiological features of cells and data analysis.

Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review

“…In practice, in order to obtain the conclusion with statistical significance, many cells need to be measured, which results in the high workload, limiting the practical application of AFM single-cell mechanical assay. Hence, automating the process of AFM single-cell mechanical measurement [154], for example, automatically moving AFM tip to the specific position of cell, will be of important significance for promoting the throughput. Besides, the response time of cells to environmental cues is ∼1 ms [138], which is much smaller than the time (more than ten minutes [65]) of acquiring one AFM mechanical map of the whole cell, causing that it is difficult to observe the real-time dynamics of cell mechanics in cellular activities.…”

A Review on Microscopic Visual Servoing for Micromanipulation Systems: Applications in Micromanufacturing, Biological Injection, and Nanosensor Assembly

“…In recent years, many micromanipulation systems have been developed for different applications, such as genetic engineering by injecting DNAs into cells [11,12], assembling nanomaterials to form nanosensors for healthcare/environmental safety applications [13,14], assembling vascular-like microtubes [15,16], and microcomponents for mobile phone applications, etc. These applications have greatly promoted the development of automation science and engineering.…”

A Research on Use of Robotics In High Rise Buildings

“…Kim et al [14] established a benefit/cost identification course of action for its applying form of robot-based structure automation approaches, that may quantify the financial viability of their automated techniques. Van Gassel [1][2][3][4][5] ran a simulation of the higher -rise building's development means, including using a structure strategy. By assessing also the construction information and the outcome of the newspaper encouraged the usage of construction procedures at holland, also affirmed that the advantages of construction procedures.…”

“…Vähäet al [3] researched on detector engineering and its prospective usage for development automation and also examined autonomous software at the principal structure processes. Taylor et al [4] outlined the prevailing automatic machines and structure robots in Japan and implied construction surroundings need to become more ordered and commanded to employ robots. Maas and van Gassel [5] reviewed the evolution of robotics and automation technologies along with its own influence on efficiency direction, structure technology, and development administration.These newspapers directed from that exactly the essential research fields have introduced the usage of robotics and automation technological innovation within the building sector as an entire and examined the analysis and growth tendencies.…”