Applications of MXene and its modified materials in skin wound repair

Abstract

The rapid healing and repair of skin wounds has been receiving much clinical attention. Covering the wound with wound dressing to promote wound healing is currently the main treatment for skin wound repair. However, the performance of wound dressing prepared by a single material is limited and cannot meet the requirements of complex conditions for wound healing. MXene is a new two-dimensional material with electrical conductivity, antibacterial and photothermal properties and other physical and biological properties, which has a wide range of applications in the field of biomedicine. Based on the pathophysiological process of wound healing and the properties of ideal wound dressing, this review will introduce the preparation and modification methods of MXene, systematically summarize and review the application status and mechanism of MXene in skin wound healing, and provide guidance for subsequent researchers to further apply MXene in the design of skin wound dressing.

MXene-Embedded Electrospun Polymeric Nanofibers for Biomedical Applications: Recent Advances

“…Previous studies have demonstrated that incorporating 2D nanosheets into electrospun nanofibers enhances the mechanical properties of membranes and improves biocompatibility, which makes them suitable for wound dressing and scaffold applications [ 140 , 141 , 142 , 143 ]. Many researchers have investigated the significance of MXenes in wound dressing applications [ 144 , 145 ]. Among many elements, titanium carbide (Ti 2 C 2 Tx) has been used mainly for wound healing due to the antimicrobial and biocompatible nature of titanium [ 145 ].…”

Fabrication of a MXene-based shape-memory hydrogel and its application in the wound repair of skin

“…23 As a photothermal component, MXene has attracted great interest because it exhibits internal light-to-heat conversion efficiency of nearly 100%. 24–27 Moreover, the rich surface functional terminals enable it to undergo solution treatment without damaging its inherent physical properties. This merit has made MXene a promising candidate for photothermal fillers for various materials ripe for photothermal conversion.…”

“…28 Li et al fabricated carbon fiber-MXene paper with superior photothermal/electrothermal-conversion performances and shielding from electromagnetic interference. 29 In addition, MXene has showed good biosafety for fibroblasts, 30,31 and can promote fibroblast migration. Thus, wound repair can be accelerated.…”

Engineering a Copper (II) Functionalized Silk Fibroin Film for Cellular Behavior Modulation

“…Current therapeutic strategies, such as skin grafting, artificial dermal replacements, and growth factor injections, are often encumbered by limitations including prohibitive costs, variable prognoses, potential immunogenicity, and stringent technical demands [3]. The constraints underscore the imperative for a universally applicable, cost-effective, and efficient wound dressing capable of sustained therapeutic delivery to drive natural repair processes [4].…”