Applications of nanomaterials for scavenging reactive oxygen species in the treatment of central nervous system diseases

An, Zhuoling; Yan, Jincong; Zhang, Ye; Pei, Renjun

doi:10.1039/d0tb01380c

Cited by 48 publications

(34 citation statements)

References 150 publications

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“…Extensive research is still being carried out to understand the interactions between plants and metallic oxide nanomaterials (NMs) [95,96]. Few metal-oxide NMs such as CeO 2 NMs, MnO 2 NMs, cobalt oxide (Co 3 O 4 ) NMs, and ferromagnetic FeO are available in mixed valence state and hence have the ability to function as nanozymes for scavenging free radicals [65,96,97].…”

Section: Metal/metalloid-based Nanoparticles For Enhancing Plant Antioxidant Defensementioning

confidence: 99%

Metal/Metalloid-Based Nanomaterials for Plant Abiotic Stress Tolerance: An Overview of the Mechanisms

Sarraf

Vishwakarma

Kumar³

et al. 2022

Plants

132

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In agriculture, abiotic stress is one of the critical issues impacting the crop productivity and yield. Such stress factors lead to the generation of reactive oxygen species, membrane damage, and other plant metabolic activities. To neutralize the harmful effects of abiotic stress, several strategies have been employed that include the utilization of nanomaterials. Nanomaterials are now gaining attention worldwide to protect plant growth against abiotic stresses such as drought, salinity, heavy metals, extreme temperatures, flooding, etc. However, their behavior is significantly impacted by the dose in which they are being used in agriculture. Furthermore, the action of nanomaterials in plants under various stresses still require understanding. Hence, with this background, the present review envisages to highlight beneficial role of nanomaterials in plants, their mode of action, and their mechanism in overcoming various abiotic stresses. It also emphasizes upon antioxidant activities of different nanomaterials and their dose-dependent variability in plants’ growth under stress. Nevertheless, limitations of using nanomaterials in agriculture are also presented in this review.

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Section: Metal/metalloid-based Nanoparticles For Enhancing Plant Antioxidant Defensementioning

confidence: 99%

Metal/Metalloid-Based Nanomaterials for Plant Abiotic Stress Tolerance: An Overview of the Mechanisms

Sarraf

Vishwakarma

Kumar³

et al. 2022

Plants

132

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“…On the other hand, the overproduction of reactive oxygen species [ 36 , 37 ], and at the next stage, lipid peroxidation [ 38 ], is an integral part of the general “adaptation-stress” syndrome [ 39 ]. In this case, the activation of free radical processes also serves as a nonspecific signal for the mobilization of the body’s defense systems [ 40 , 41 , 42 , 43 ], including the activation of antioxidant defense mechanisms [ 44 ], which is a typical reaction of the biological system to an effect that unbalances it from the state of physiological equilibrium [ 45 , 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Deuterium Level Supports Resistance of Neurons to Glucose Deprivation and Hypoxia: Study in Cultures of Neurons and on Animals

et al. 2021

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The effect of a reduced deuterium (D) content in the incubation medium on the survival of cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied the effect of a decrease in the deuterium content in the rat brain on oxidative processes in the nervous tissue, its antioxidant protection, and training of rats in the T-shaped maze test under hypoxic conditions. For experiments with cultures of neurons, 7–8-day cultures of cerebellar neurons were used. Determination of the rate of neuronal death in cultures was carried out using propidium iodide. Acute hypoxia with hypercapnia was simulated in rats by placing them in sealed vessels with a capacity of 1 L. The effect on oxidative processes in brain tissues was assessed by changes in the level of free radical oxidation and malondialdehyde. The effect on the antioxidant system of the brain was assessed by the activity of catalase. The study in the T-maze was carried out in accordance with the generally accepted methodology, the skill of alternating right-sided and left-sided loops on positive reinforcement was developed. This work has shown that a decrease in the deuterium content in the incubation medium to a level of −357‰ has a neuroprotective effect, increasing the survival rate of cultured neurons under glucose deprivation. When exposed to hypoxia, a preliminary decrease in the deuterium content in the rat brain to −261‰ prevents the development of oxidative stress in their nervous tissue and preserves the learning ability of animals in the T-shaped maze test at the level of the control group. A similar protective effect during the modification of the 2H/1H internal environment of the body by the consumption of DDW can potentially be used for the prevention of pathological conditions associated with the development of oxidative stress with damage to the central nervous system.

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“…[134] Noble metal nanoparticles such as Au, Pd, and Pt demonstrate remarkable catalytic activities and intrinsic antioxidant properties. [135,136] Functionalizing these nanomaterials with various ligands can greatly improve their biocompatibility and broaden their biomedical application potentials. To this end, efforts have been made to adjust the size and morphology of Pt nanoparticles (NPs) with a protective layer of sodium alginate to enhance their dispersibility, stability, and possibility of infusing additional surface features, nanogel preparation, and diverse applications in other fields.…”

Section: Nanozymesmentioning

confidence: 99%

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.

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Applications of nanomaterials for scavenging reactive oxygen species in the treatment of central nervous system diseases

Abstract: Nanomaterials with excellent ROS-scavenging ability and biodistribution are considered as promising candidates in alleviating oxidative stress and restoring redox balance in CNS diseases, further facilitating the function recovery of the CNS.

Cited by 48 publications

References 150 publications

Metal/Metalloid-Based Nanomaterials for Plant Abiotic Stress Tolerance: An Overview of the Mechanisms

Metal/Metalloid-Based Nanomaterials for Plant Abiotic Stress Tolerance: An Overview of the Mechanisms

Reduction of Deuterium Level Supports Resistance of Neurons to Glucose Deprivation and Hypoxia: Study in Cultures of Neurons and on Animals

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

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